| Sunday, June 26, 2016 |
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| 7:00 AM–8:00 AM |
BDRB EDITORIAL BOARD MEETING — Republic A |
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| 7:00 AM–8:00 AM |
DINE WITH A TERATOLOGY AMBASSADOR – Republic B |
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(Advance Signup is Required) |
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| 7:00 AM–6:00 PM |
REGISTRATION OPEN – Texas Ballroom Foyer |
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| 7:00 AM–6:00 PM |
SPEAKER READY ROOM OPEN – Crockett A |
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| 7:30 AM–8:00 AM |
MORNING COFFEE AND PASTRIES – Texas Ballroom A |
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| 8:00 AM–8:15 AM |
PRESIDENT'S WELCOME – Texas Ballroom D |
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Society for Birth Defects Research and Prevention President, Tacey E.K. White, Aclairo® Pharmaceutical Development Group, Inc. |
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| 8:15 AM–9:00 AM |
JOSEF WARKANY LECTURE – Texas Ballroom D |
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(Joint with DNTS and OTIS) |
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Framing Our Birth Defects Questions with Systems Biology: Learning from Our Mentors |
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Chairperson: Tacey E.K. White, Aclairo® Pharmaceutical Development Group, Inc. |
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Lecturer: Elaine M. Faustman, University of Washington |
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| 9:00 AM–12:00 Noon |
STUDENT/POSTDOCTORAL FELLOW PLATFORM SESSION 1 – Texas Ballroom D |
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Organized by the Student Affairs Committee |
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Chairperson: Dana L. Shuey, Incyte |
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Presenting author is underlined. |
| 9:00 AM–9:15 AM |
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Introduction
Dana L. Shuey, Incyte |
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| 9:15 AM–9:30 AM |
1 |
Physiological and Ethanol-Enhanced Embryonic and Fetal DNA Oxidation in Brca1 Knockout Progeny
Drake D1, Wells PG1,2. 1Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada, 2Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada. |
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| 9:30 AM–9:45 AM |
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Altered Expression of Placental Proteins Related to Angiogenesis in Pregnancies Exposed to Alcohol
Holbrook BD1, Bishop S2, Williams S2, Cano S2, Davies S3, Bakhireva LN2, Savage DD3. 1Department of Obstetrics and Gynecology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, United States, 2Department of Pharmacy Practice and Administrative Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM, United States, 3Department of Neurosciences, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, United States. |
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| 9:45 AM–10:00 AM |
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Teratogenicity of the Herbal Supplement Vinpocetine in Harlan-Sprague Dawley Rats
Catlin NR1, Foster P1, Mylchreest E2, Miller L2, Cunny HC1, McIntyre BS1. 1Division National Toxicology Program, NIEHS, Durham, NC, United States, 2Southern Research Institute, Birmingham, AL, United States. |
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| 10:00 AM–10:15 AM |
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Break—Texas Ballroom A |
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| 10:15 AM–10:30 AM |
4 |
Reduced Expression of the Long Noncoding RNA GALNR Mediates High Glucose-Induced Apoptosis by Up-Regulating Gadd45α in Diabetic Embryopathy
Dong D, Yang P. University of Maryland, Baltimore, Baltimore, MD, United States. |
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| 10:30 AM–10:45 AM |
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Therapeutic Potential of RNAi Silencing CRMP-4 Combined with MSCs in Animal Models with Spina Bifida Aperta
Cao SY, Yuan ZW. China Medical University, Shenyang, China. |
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| 10:45 AM–11:00 AM |
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Determining Developmental Neurotoxicity of Pesticides Utilizing Metabolomic Profile from Neural Progenitor Cells
McKenzie M1,2, Amosu M1,2, Wu X1,2, Wallace S3, Henderson M4, Bian X2, Lu K1,2, Stice S2,3, Smith M A1,2. 1Environmental Health Science University of Georgia, Athens, GA, United States, 2Regenerative Bioscience Center University of Georgia, Athens, GA, United States, 3ArunA Biomedical Inc., Athens, GA, United States, 4Environmental Protection Agency, Athens, GA, United States. |
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| 11:00 AM–11:15 AM |
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The Association between Maternal Diabetes and Congenital Heart Defect Phenotypes in Texas and Updated Meta-Analysis
Hoang TT1, Marengo LK2, Mitchell LE1, Canfield MA2, Agopian AJ1. 1University of Texas School of Public Health, Houston, TX, United States, 2Texas Department of State Health Services, Houston, TX, United States. |
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| 11:15 AM–11:30 AM |
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Harm-Reduction Tobacco Products Interfere with the Differentiation of Craniofacial Bone
Sparks NRL1, Bondesson M3, zur Nieden NI2. 1Environmental Toxicology Graduate Program, University of California, Riverside, Riverside, CA, United States, 2Cell Biology and Neuroscience and Stem Cell Center, University of California, Riverside, Riverside, CA, United States, 3Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, United States. |
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| 11:30 AM–11:45 AM |
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Exposure of Organogenesis-Stage Embryos to Hydroxyurea Alters the Expression of P53-Family Related Genes that Are Involved in Limb Development
El Husseini N, Hales B. McGill University, Montreal, QC, Canada. |
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| 11:45 AM–12:00 Noon |
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An Evaluation of ToxCast Angiogenic Disruptors for Effects on Mitochondrial Bioactivity Profiles
Leung MCK1,2, Kapraun DF1, Williams AJ1, Knudsen TB1. 1United States Environmental Protection Agency, Research Triangle Park, NC, United States, 2Oak Ridge Institute for Science and Education, Oak Ridge, TN, United States. |
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| 10:00 AM–10:30 AM |
SPOUSE AND GUEST MEET-AND-GREET – Republic A |
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(Open to Society for Birth Defects Research and Prevention, DNTS, and OTIS Spouses and Guests) |
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| 12:00 Noon–1:30 PM |
LUNCH ON YOUR OWN |
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| 12:00 Noon–1:30 PM |
AWARDS COMMITTEE MEETING – Crockett B |
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| 12:00 Noon–1:30 PM |
PUBLICATIONS COMMITTEE MEETING – Crockett C |
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| 12:00 Noon–1:30 PM |
SCIENCE COMMITTEE MEETING – Crockett D |
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| 12:00 Noon–1:30 PM |
STUDENT AND POSTDOCTORAL LUNCH WORKSHOP – Texas Ballroom D |
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Advancing Your Career in Birth Defects Research and Prevention (W1) |
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Chairpersons: Christine Perdan Curran, Northern Kentucky University and Dana L. Shuey, Incyte |
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(Advance Registration Required) |
| 12:00 Noon–12:05 PM |
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Introduction |
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| 12:05 PM–12:25 PM |
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Publishing in the Sciences |
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Michel Vekemans, Hopital Necker-Enfants Malades |
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| 12:25 PM–12:45 PM |
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The Most Common Mistakes in Statistical Analysis: How to Recognize and Avoid Them |
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Charles V. Vorhees, Cincinnati Children's Hospital Medical Center |
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| 12:45 PM–1:05 PM |
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Finding Your Place in a Transdisciplinary World |
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Melissa S Tassinari, US Food and Drug Administration |
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| 1:05 PM–1:25 PM |
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Growing Pains: Moving from Mentee to an Independent Career |
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Sarah G. Obican, University of South Florida |
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| 1:25 PM–1:30 PM |
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Discussion |
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| 1:30 PM–2:00 PM |
F. CLARKE FRASER NEW INVESTIGATOR AWARD – Texas Ballroom D |
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Of Mice, Math, and Modeling (L2) |
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Chairperson: Bruce K. Beyer, Sanofi U.S. Inc. |
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Presented by Marilyn Preus |
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Lecturer: Nicole Churchill Kleinstreuer, NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, NIEHS |
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| 2:00 PM–2:30 PM |
JAMES G. WILSON PUBLICATION AWARD– Texas Ballroom D |
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A Comparison of ToxCast Test Results with In Vivo and Other In Vitro Endpoints for Neuro, Endocrine, and Developmental Toxicities: A Case Study Using Endosulfan and Methidathion |
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Chairperson: Norbert Makori, WIL Research Laboratories |
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Lecturer: Marilyn H. Silva, California Environmental Protection Agency |
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| 2:30 PM–5:30 PM |
THE STATE OF THE ART OF TESTING DRUGS: PRESENT AND FUTURE SYMPOSIUM – Texas Ballroom D |
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Chairpersons: Kenjie Amemiya, Genentech and Elise Madison Lewis, Charles River Laboratories |
| 2:30 PM–3:00 PM |
S1 |
Revisions to the ICH S5 Guideline: Thinking Outside the Box |
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Anthony M. DeLise, Novartis Pharmaceuticals Corporation |
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| 3:00 PM–3:30 PM |
S2 |
Hitting the Target with DARTS(tudies): Using Biology to Assess Reproductive Risk |
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Kenjie Amemiya, Genentech |
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| 3:30 PM–4:00 PM |
S3 |
Alternatives in Developmental Toxicology: How Far We Have Come (and Have Left To Go) |
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Kimberly C. Brannen, Merck |
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| 4:00 PM–4:15 PM |
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Break – Texas Ballroom A |
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| 4:15 PM–4:45 PM |
S4 |
Integrating Alternative Developmental Toxicity Assays for Pharmaceutical Risk Assessment |
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Maia L. Green, Merck |
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| 4:45 PM–5:15 PM |
S5 |
Harmonization of the Pediatric Nonclinical Testing Guidelines: The Who, What, When, and Why of ICH S11 |
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Susan Bielmeier Laffan, GlaxoSmithKline |
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| 5:15 PM–5:30 PM |
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Discussion |
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| 2:30 PM–5:30 PM |
PREGNANCY REGISTRY UPDATES SYMPOSIUM (Joint with OTIS) – Texas Ballroom E |
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Chairpersons: Christina D. Chambers, University of California San Diego and Lewis B. Holmes, MassGeneral Hospital for Children |
| 2:30 PM–2:35 PM |
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Introduction |
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| 2:35 PM–2:55 PM |
S6 |
Gestational Age at Enrollment |
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Sonia Hernandez-Diaz, Harvard School of Public Health |
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| 2:55 PM–3:15 PM |
S7 |
Prevalence Reference Rates for Pregnancy Registries and for Labeling |
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Leyla Sahin, US Food and Drug Administration |
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| 3:15 PM–3:35 PM |
S8 |
Modern Methods of Pregnancy Registry Recruitment: Successes and Challenges |
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Jennifer Zellner, University of California, San Diego |
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| 3:35 PM–3:55 PM |
S9 |
Minor Anomalies: An Unreliable Outcome for Pregnancy Registries |
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Lewis B. Holmes, MassGeneral Hospital for Children |
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| 3:55 PM–4:10 PM |
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Break – Texas Ballroom A |
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| 4:10 PM–4:25 PM |
S11 |
Improving Safe Use of Medications during Pregnancy: The Roles of Patients, Physicians, and Pharmacists
Lynch MM1, Amoozegar J1, McClure EM1, Squiers LB1, Broussard CS2 , Lind JN2, Polen KN2, Frey MT2, Gilboa SM2, Biermann, J3. 1RTI International, Research Triangle Park, NC, United States, 2Centers for Disease Control and Prevention, Atlanta, GA, United States, 3March of Dimes Foundation, White Plains, NY, United States.
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| 4:25 PM–4:40 PM |
S12 |
Integration of a Teratologist's Clinical Review of Birth Defects Reported through Pharmacovigilance
Golembesky A1, Scheuerle A2. 1UCB Pharma, Raleigh, NC, United States, 2University of Texas Southwestern Medical Center, Dallas, TX, United States. |
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| 4:40 PM–4:55 PM |
S13 |
Time Trends of Microcephaly in Texas: What's Up?
Langlois PH1, Scheuerle AE2, Marengo LK1, Hoyt AT1, Ethen MK1, Canfield MA1. 1Texas Department of State Health Services, Austin, TX, United States, 2University of Texas Southwestern Medical Center, Dallas, TX, United States. |
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| 4:55 PM–5:30 PM |
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Discussion |
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| 5:30 PM–6:00 PM |
PATRICIA RODIER MID-CAREER AWARD FOR RESEARCH AND MENTORING – Texas Ballroom D |
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(Joint with DNTS) |
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Research on Long Term Outcomes following Prenatal Exposures: Rarely Studied But Sorely Needed (L3) |
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Chairpersons: Bruce K. Beyer, Sanofi U.S. Inc. and Patricia Janulewicz, Boston University |
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Lecturer: Christina D. Chambers, University of California San Diego |
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| 6:00 PM–7:30 PM |
WELCOME RECEPTION, STUDENT AND POSTDOCTORAL FELLOW RESEARCH SHOWCASE, AND EXHIBITS – Texas Ballroom B
(Joint with DNTS) |
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| 7:30 PM–9:00 PM |
COMMUNICATIONS WORKING GROUP MEETING – Republic B |
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