| Monday, June 26, 2017 |
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| 7:00 AM–6:00 PM |
REGISTRATION OPEN – Aspen Foyer |
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| 7:00 AM–6:00 PM |
SPEAKER READY ROOM OPEN – Crestone Peak |
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| 7:00 AM–8:00 AM |
2018 PROGRAM COMMITTEE MEETING – Mt. Princeton |
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| 7:00 AM–8:00 AM |
BREAKFAST WITH THE TERATOLOGY MENTORS – Mt. Oxford
(Advance Signup Is Required) |
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Chairpersons: Dana L. Shuey. Incyte and Dinesh J. Stanislaus, GlaxoSmithKline |
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| 7:30 AM–8:00 AM |
MORNING COFFEE AND PASTRIES – Aspen Foyer
(Joint with DNTS) |
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| 8:00 AM–9:00 AM |
KEYNOTE ADDRESS – Aspen Ballroom
(Joint with DNTS) |
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Cannabis in Colorado: The Impact of Legalization on Children and Families (L2) |
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Chairpersons: Alan M. Hoberman, Charles River Laboratories and Gregg D. Stanwood, Florida State University |
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Larry I. Wolk, Colorado Department of Public Health and Environment |
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| 9:15 AM–12:00 Noon |
RSA/FASD-SG, Society for Birth Defects Research and Prevention, OTIS, AND
DNTS EXCHANGE SYMPOSIUM – Aspen Ballroom |
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(Joint with DNTS) |
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Evaluation of Fetal Risk in the Context of Multiple Co-Exposures |
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Chairpersons: Ludmila Bakhireva, University of New Mexico and Jeffrey R. Wozniak, University of Minnesota |
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| 9:15 AM–9:25 AM |
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Introduction: Methodological Challenges of Evaluating the Effect of Multiple Exposures |
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Ludmila Bakhireva, University of New Mexico |
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| 9:25 AM–9:50 AM |
S16 |
Defining the Human Exposome |
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Cynthia F. Bearer, University of Maryland |
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| 9:50 AM–10:15 AM |
S17 |
PK/PD Modelling for Multiple Exposures in Pregnancy |
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Donald R. Mattison, Risk Sciences International |
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| 10:15 AM–10:40 AM |
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Networking Break – Aspen Foyer |
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| 10:40 AM–11:05 AM |
S18 |
Alcohol and Nicotine-Induced Epigenetic Changes (miRNAs) |
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Rajesh C. Miranda, Texas A&M Health Sciences Center |
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| 11:05 AM–11:30 AM |
S19 |
Epigenetic Changes Induced by Prenatal Nicotine and Cocaine Exposure |
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Pradeep Bhide, Florida State University |
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| 11:30 AM–11:35 AM |
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Concluding Remarks |
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Jeffrey R. Wozniak, University of Minnesota |
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| 11:35 AM–12:00 Noon |
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Panel Discussion |
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| 9:05 AM–11:45 AM |
PLATFORM SESSION 2 – Colorado Ballroom B |
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Mechanistic and Clinical Teratology |
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Chairpersons: John M. DeSesso and Amy L. Williams, Exponent, Inc. |
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Presenting author is underlined. |
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| 9:05 AM-9:15 AM |
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Introduction |
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| 9:15 AM-9:30 AM |
11 |
Prediction of Developmental Toxicity Potential Dictated by In Vivo Exposures with a Biomarker-Based Human Pluripotent Stem Cell Assay
Palmer JA, Smith AM, Colwell MR, Smart BJ, Ludwig MA, Burrier RE, Donley ELR, Kirchner FR. Stemina Biomarker Discovery, Inc., Madison, WI, United States |
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| 9:30 AM-9:45 AM |
12 |
DNA Hypermethylation in Tight Junction Pathway Is Associated with Neural Tube Defects: A Genome-Wide DNA Methylation Analysis
Ren A1,2, Wang LL1,2, Lin S1,2, Zhang J1,2, Tian T1,2, Huang Y1,2. 1Institute of Reproductive and Child Health, Peking University, Beijing, China, 2Ministry of Health Key Laboratory of Reproductive Health, Peking University, Beijing, China. |
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| 9:45 AM-10:00 AM |
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Toxicogenomic Profiling of BDE-47 Effects in Human Primary Villous Cytotrophoblasts
Robinson JF, Hamilton EG, Ona K, Puckett KA, Kapidzic M, Fisher SJ. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California-San Francisco, San Francisco, CA, United States. |
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| 10:00 AM-10:15 AM |
14 |
Targeted Dnmt3a Deletion Ameliorates Maternal Diabetes-Induced DNA Hypermethylation and Neural Tube Defects
Yang P, Xu C, Yang P. University of Maryland School of Medicine, Baltimore, MD, United States. |
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| 10:15 AM-10:30 AM |
15 |
VDR Regulates Skeleton Development through MiR-140-5p by Transcriptional Regulation
Luo W, Yang L, Dong Y, Kong J, Yuan Z, Zhao Q. Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. |
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| 10:30 AM-10:45 AM |
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Break—Aspen Foyer |
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| 10:45 AM-11:00 AM |
16 |
Biliary Atresia and Maternal Nutrient Intake
Carmichael SL1, Ma C1, Van Zutphen A2,3, Moore CA4, Shaw GM1. 1Division of Neonatology and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, United States, 2Bureau of Environmental and Occupational Epidemiology, New York State Department of Health, Albany, NY, United States, 3Department of Epidemiology and Biostatistics, University at Albany School of Public Health, Rensselaer, NY, United States, 4National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States. |
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| 11:00 AM-11:15 AM |
17 |
Challenges of Species Selection for Development and Reproductive Toxicity Studies with A Dopamine Agonist
Zhuang Q, Rasmussen AD, Jensen KG, Bernholm K, Northeved H. Nonclinical Safety Research, H. Lundbeck A/S, Copenhagen, Denmark. |
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| 11:15 AM-11:30 AM |
18 |
Justifying Mandatory Food Fortification with Folic Acid: Benefits Beyond Preventing Neural Tube Defects
Mills JL. Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, United States. |
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| 11:30 AM-11:45 AM |
19 |
An Evaluation of Household Environments and Zika Risk Perceptions, Prevention Behaviors, and Prevention Knowledge among Pregnant Women in Puerto Rico
Turay KR1, Earle-Richardson G1, Medina-Martínez G2, Romero-Pérez M2, Chavez P3, Vega MC5, Thomas D4,5, Rivera-Garcia B5, Prue C1. 1Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Atlanta, GA, United States, 2Caduceus Staffing, Atlanta, GA, United States, 3Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, GA, United States, 4Centers for Disease Control and Prevention, Office of Public Health Preparedness and Response, Atlanta, GA, United States, 5Puerto Rico Department of Health, San Juan, PR, United States. |
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| 12:00 Noon–1:30 PM |
LUNCH ON YOUR OWN |
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| 12:00 Noon–1:30 PM |
PAST PRESIDENTS' AND HONOREES' LUNCHEON – Maroon Peak |
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(By Invitation Only) |
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| 12:00 Noon–1:30 PM |
MEMBERSHIP COMMITTEE MEETING – Mt. Yale |
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| 12:00 Noon–1:30 PM |
PUBLIC AFFAIRS COMMITTEE MEETING – Mt. Princeton |
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| 1:30 PM–4:50 PM |
MARCH OF DIMES SYMPOSIUM – Aspen Ballroom
The Complexities of Caring for the Pregnant and Lactating
Patient with Chronic Inflammatory Disease: Maternal and Fetal Considerations
(Joint with OTIS) |
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Chairpersons: Christina D. Chambers, University of California-San Diego and Melissa S. Tassinari, Independent Consultant |
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| 1:30 PM–1:35 PM |
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Introduction |
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| 1:35 PM–1:55 PM |
S20 |
Overview: Complexity of Disease Management in Pregnancy and Lactation, Consequences of Chronic Disease Itself and Polypharmacy, Use of Asthma and Lupus As Examples |
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Megan E.B. Clowse, Duke University |
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| 1:55 PM–2:15 PM |
S21 |
Case Study: Asthma in Pregnancy |
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Jennifer A. Namazy, Scripps Clinic Mission Valley |
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| 2:15 PM–2:35 PM |
S22 |
Case Study: Lupus in Pregnancy |
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Megan E.B. Clowse, Duke University |
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| 2:35 PM–2:55 PM |
S23 |
Missing Data |
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Christine Stallman, University of Arizona and MotherToBaby Arizona |
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| 2:55 PM–3:15 PM |
S24 |
Long Term Effects of Maternal Factors on Child’s Risk for Autism and Other Neurodevelopmental Concerns |
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Irva Hertz-Picciotto, University of California-Davis |
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| 3:15 PM–3:35 PM |
S25 |
Chronic Maternal Immune Mediated Diseases and Their Treatments: How Do We Design Good Quality Studies to Evaluate Neurodevelopment in the Offspring? |
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Gail S. Ross, Cornell University |
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| 3:35 PM–3:50 PM |
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Break - Aspen Foyer |
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| 3:50 PM–4:10 PM |
S26 |
Lactation and Medications |
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Philip O. Anderson, University of California-San Diego |
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| 4:10 PM–4:30 PM |
S27 |
Pregnancy and Lactation Labeling Rule (PLLR): Placement of Human Data in Labeling |
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Tamara Johnson, US Food and Drug Administration |
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| 4:30 PM–4:50 PM |
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Panel Discussion |
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| 1:30 PM–5:30 PM |
MALE BREAST HEALTH: THE ROLE OF DEVELOPMENTAL
EXPOSURES ON CHILDHOOD AND ADULT OUTCOMES SYMPOSIUM – Colorado Ballroom A |
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Chairpersons: Susan Y. Euling, US Environmental Protection Agency and Suzanne E. Fenton, National Institute of Environmental Health Sciences |
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| 1:30 PM–2:15 PM |
S28 |
Species Differences in Mammary Gland Development and Susceptibility to Environmental Chemicals: Human–Animal Species Comparisons |
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Ana M. Soto, Tufts University |
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| 2:15 PM–2:55 PM |
S29 |
Male Rat Mammary Gland Effects after Developmental Exposure to Environmental Chemicals |
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Suzanne E. Fenton, National Institute of Environmental Health Sciences |
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| 2:55 PM–3:35 PM |
S30 |
Genesis of Male Breast Cancer: An Epidemiologic Perspective |
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Louise A. Brinton, Division of Cancer Epidemiology and Genetics, NCI |
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| 3:35 PM–3:50 PM |
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Break – Aspen Foyer |
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| 3:50 PM–4:30 PM |
S31 |
The Role of Environmental Factors in Pubertal Gynecomastia |
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Susan Y. Euling, US Environmental Protection Agency |
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| 4:30 PM–5:10 PM |
S32 |
The Development of Pubertal Gynecomastia and the Association to Endogenous Hormones, Growth, and Body Composition |
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Mikkel G. Mieritz, Rigshospitalet |
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| 5:10 PM–5:30 PM |
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Discussion |
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| 5:30 PM–7:30 PM |
POSTER SESSION 1 AND EXHIBITS ATTENDED – Capitol Peak Ballroom
(Joint with DNTS and OTIS) |
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Society for Birth Defects Research and Prevention Posters P1–P14
DNTS Posters 1-21
OTIS Posters 1–14 |
P1 Overview of Zika en Embarazadas y Niños en Colombia (ZEN): A Prospective
Cohort Study Examining Zika Virus Infection during Pregnancy and Risk of
Adverse Pregnancy, Birth, and Infant Outcomes
Colombian Instituto Nacional de Salud1,
US Centers for Disease Control and Prevention2, Anderson KN2.
1Colombian Instituto Nacional de Salud, Bogota, Colombia, 2US
Centers for Disease Control and Prevention, Atlanta, GA, United States.
P2 Assessing Teratogenicity from the Clustering of
Abnormal Phenotypes in Individual Zebrafish Larvae
Ali S2, Aalders J1,
Jong T1, Richardson M1. 1Sylvius Laboratory, Institute
of Biology, Leiden University, Leiden, The Netherlands, 2Department of
Zoology, The University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.
P3 Quantitative Prediction of Microcephaly
Utilizing Cell Agent-Based Modeling: Profiling the Centrosome Cycle
Zurlinden TJ1, Saili KS1,
Spencer RS2, Baker NC2, Knudsen TB1. 1National
Center for Computational Toxicology, US EPA, Research Triangle Park, NC, United
States, 2Leidos, Research Triangle Park, NC, United States.
P4 Computational Modeling of the Neurovascular
Unit to Predict Microglia Mediated Effects on Blood-Brain Barrier Formation
Zurlinden TJ1, Saili KS1,
Spencer RS2, Baker NC2, Knudsen TB1. 1National
Center for Computational Toxicology, US EPA, Research Triangle Park, NC, United
States, 2Leidos, Research Triangle Park, NC, United States.
P5 Cardiovascular Ultrasound of Neonatal Long
Evans Rats Exposed Prenatally to Trichloroacetic Acid: Effects on Heart Rate,
Ejection Fraction, and Cardiac Output
Narotsky MG1, Thompson LC2,
Manley AL3, Ola O4. 1Toxicity Assessment Division,
ORD, US Environmental Protection Agency, Research Triangle Park, NC, United States,
2Environmental & Public Health Division, US Environmental Protection Agency,
Research Triangle Park, NC, United States, 3Oak Ridge Institute for Science
and Education, US Environmental Protection Agency, Research Triangle Park, NC, United
States, 4Student Contractor, US Environmental Protection Agency, Research
Triangle Park, NC, United States.
P6 Hazard Screening Approaches for Identifying
Developmental and Reproductive Toxicity in the Workplace
Pacheco Shubin SE1, Cohen JM2, Dodge DG3,
Lewandowski TA1. 1Gradient, Seattle, WA, United States,
2Gradient, Cambridge, MA, United States, 3Gradient, Bend, OR, United
States.
P7 Systems Toxicology Model of Neurovascular
Development
Saili KS1, Zurlinden TJ1,
Baker NC2, Knudsen TB1. 1National Center for Computational
Toxicology, US EPA, Research Triangle Park, NC, United States, 2Leidos,
Research Triangle Park, NC, United States.
P8 Orofacial Clefting in Response to Hedghog
Pathway Antagonists is Recapitulated in a Practical
Epithelial–Mesenchymal 3D Culture Model
Johnson BP2, Vitek RM2,
Fink DM1, Chung H1, Geiger P2, Beebe DJ2,
Lipinski RJ1. 1University of Wisconsin, Department of Comparative
Biosciences, Madison, WI, United States, 2University of Wisconsin, Department
of Biomedical Engineering, Madison, WI, United States.
P9 Developmental Neurotoxicity after Exposure to
Pesticides: Adding a Biotransformation Component Impacts the Pathways Affected
in Human Neural Progenitor Cells (hN2)
McKenzie EM1, Amosu OM1,
Smith MA1, Stice SL1,2. 1University of Georgia,
Athens, GA, United States, 2ArunA Biomedical, Inc, Athens, GA, United
States.
P10 Characterizing the Effect of Embryonic Ethanol
Exposure on Cranial Nerve Development in Zebrafish Embryos Mutant for the
Ethanol-Sensitive Allele, vangl2
Buckley DM, Eberhart
JK. University of Texas–Austin, Austin, TX, United States.
P11 The Effects of Quaternary Ammonium Compounds on
Development of the Microbiome
McDonald VA1, Hrubec TC2.
1Department Biological Sciences, VA Tech, Blacksburg, VA, United States,
2E. Via College of Osteopathic Medicine, VA Campus, Blacksburg, VA, United
States.
P12 Abundance of Household Products Contain
Quaternary Ammonium Compounds
Hrubec TC1,2, DiPeppi R1.
1E. Via College of Osteopathic Medicine, VA Campus, Blacksburg, VA, United
States, 2VA-MD College of Veterinary Medicine, Blacksburg, VA, United
States.
P13 Follow the White Rabbit: Does the Source of
Time-Mated New Zealand White Rabbits Impact Maternal or Developmental
Parameters?
Olitan TA, Rayhon SL, McNerney ME, Thompson KE. Bristol-Myers Squibb, New Brunswick,
NJ, United States.
P14 A Comparison of the Embryofetal Development
Data Collected from New Zealand White (Crl:KBL[NZW]) Rabbits at Several
Teratology Laboratories
Pouliot L1, Marsden E2,
Lewis EM3, Robinson K1. 1Charles River, Montréal,
QC, Canada, 2Charles River, Lyon, France, 3Charles River,
Horsham, PA, United States.
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| 7:30 PM–10:00 PM |
Society for Birth Defects Research and Prevention AND
MARTA STUDENT CAREER EVENT – Mt. Sopris
(Open to Society for Birth Defects Research and Prevention, DNTS, and OTIS Student and Postdoctoral Fellows) |
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