Education Course Coffee and Pastries
(Education Course Session 1 Registrants Only)

(Separate Registration Required)

Education Course Session 2
Stem Cells: The Role and Promise in Birth Defects Research
(Separate Registration Required)

Council 1 Meeting
(All current and incoming Council members as well as current Committee Chairs and Vice Chairs attend Council 1.)

Josef Warkany Lecture
(Joint with DNTS)
Chairperson: Anthony M. DeLise, Novartis Pharmaceuticals Corporation
Lecturer: Christina D. Chambers, University of California San Diego

Past Presidents’ and Honorees’ Luncheon
(By Invitation Only)

F. Clarke Fraser New Investigator Award
Chairperson: Bethany R. Hannas, Eli Lilly and Company
Lecturer: Jeremy M. Schraw, Baylor College of Medicine

James G. Wilson Publication Award
An Improved Multicellular Human Organoid Model for the Study of Chemical Effects on Palatal Fusion
Chairperson: Wendy Nembhard, University of Arkansas for Medical Sciences
Lecturer: Cynthia J. Wolf, US Environmental Protection Agency

Innovator Award Finalists Platform Session 2
Organized by the Awards Committee
Chairperson: Bethany R. Hannas, Eli Lilly and Company

Patricia Rodier Mid-Career Award for Research and Mentoring
Reproductive Toxicology in Industry: Research and Mentoring are the Special Sauce
(Joint with DNTS)
Chairpersons: Bethany R. Hannas, Eli Lilly and Company; and
Stephanie A Godleski, Rochester Institute of Technology
Lecturer: Christopher J. Bowman, Pfizer Inc.

Multidisciplinary Research Needs Workshop
Organized by the Science Committee
Chairpersons: Kary E. Thompson, Janssen Pharmaceuticals; and
Suzanne E. Fenton, NC State University

Poster Session 1
(Joint with DNTS)
Sponsored by WuXi AppTec

BDRP Posters P1–P24
            LB1-LB4
DNTS Posters 1-11

Keynote Lecture
Putting the Pieces Together: Head to Toe (L1)
(Joint with DNTS) Chairperson: Philip J. Lupo, Baylor College of Medicine
Speaker: Wendy K. Chung, Boston Children’s Hospital

Congenital Anomalies in Minoritized Populations: An Overview of Factors Affecting Prevalence and Outcomes Symposium
(Joint with DNTS)
Chairpersons: Jeremy Schraw, Baylor College of Medicine; and
Wendy Nembhard, University of Arkansas for Medical Sciences

Maternal and offspring demographic characteristics are associated with birth defects prevalence and outcomes, but the causes of these disparities are poorly understood and little discussed. This session will address the epidemiology of congenital anomalies in minoritized populations. How factors such as race, ethnicity, insurance status, neighborhood characteristics, and public health policy relate to the prevalence of birth defects and to survival among affected infants and children will be discussed. Recommendations for leveraging birth defect surveillance data to understand and mitigate birth defect disparities will be provided. The session is intended for researchers, clinicians, and public health professionals interested in birth defects or the health outcomes of people belonging to minoritized populations.

Platform Session 3
Christopher J. Bowman, Pfizer Research & Development; and
Julie M. Petersen, Boston University School of Public Health

Professional Development Lunch Workshop
Science Communication
(Separate Registration Required)
Organized by the Student Affairs Committee
Chairpersons: Christopher J. Bowman, Pfizer Inc.; and Deirdre K. Tucker, Crinetic's Pharmaceuticals

The Professional Development Workshop on Science Communication is designed for beginning and experienced scientists and will provide advice and techniques on how to effectively communicate complex scientific concepts, research, and the impacts of that research. Attendees will learn key attributes of an “elevator pitch” to simplify complicated science for short and effective communication. Practical exercises will be included to develop key messages and adjust the delivery of a presentation based on the audience and purpose. This workshop is organized by the Student Affairs Committee. Attendees of all career stages are encouraged to participate. Separate registration is required to attend this workshop. Trainees may register at no additional charge, and other attendees pay a nominal fee.

Agnish Fellowship Lecture
The Identification of Human Teratogens Using a Clinical Approach
Chairperson: Terry C. Hrubec, E. Via Virginia College of Osteopathic Medicine
Lecturer: Kenneth L. Jones, UCSD, CA MotherToBaby

Chemicals Altering Signaling Molecules and Developmental Pathways Symposium
(Joint with DNTS)
Organized by the Public Affairs Committee

Chairpersons: Christine Perdan Curran, Northern Kentucky University; and
Rajesh C. Miranda, Texas A&M Health Science Center

Prevention of birth defects begins with understanding the exposures and biochemical pathways that lead to adverse pregnancy outcomes. This symposium will include a discussion of widespread exposures and their interaction with signaling molecules that are crucial to normal embryonic and fetal development. Session speakers will discuss the role of common exposures on specific pathways associated with neural development and function as well as other critical organ systems. A variety of model systems will be reviewed with a discussion of their value and how data collected can be used in risk assessment and regulation.

Genetic and Environmental Factors Driving Facial Morphology and Dysmorphology Symposium

Chairpersons: Seth M. Weinberg, University of Pittsburgh; and
John R. Shaffer, University of Pittsburgh

We have seen incredible progress in our understanding of how genes and environmental factors impact facial variation, from the subtle features that give us our unique appearance to life-altering malformations. This is due in part to groundbreaking advances in imaging, computational modeling, and genome-altering technologies. In this interdisciplinary symposium, we examine the complex forces that give rise to facial morphology and dysmorphology—specifically orofacial clefting.

Poster Session 2
(Joint with DNTS)
BDRP Posters P25-P48
            LB5-LB8
DNTS Posters 12-22

Neural Tube Defects in a Post-Folate Fortified World Symposium
(Joint with DNTS)
Chairpersons Robert M. Cabrera, Baylor College of Medicine; and
Richard H. Finnell, Baylor College of Medicine

Spina bifida (SB) is the most frequently encountered neural tube defect (NTD). Up to 70% of NTDs are attributed to genetic factors, while the intrauterine environment tips the balance to neurulation failure in at-risk individuals. Despite aggressive campaigns for folic acid (FA) supplementation and fortification of the food supply in over 85 nations, there are substantial gaps in understanding the risks and mechanisms that underlie SB. These gaps limit efforts to find more effective treatment and prevention going beyond FA. Indicators for a genetic component are many, and while NTDs can be familial after one SB-affected pregnancy, the recurrence risk is 1 in 20 and even after two affected pregnancies, the recurrence risk does not rise above 10%, strongly arguing against a monogenic causation. Pharmaceutical compounds including anti-seizure medications have long been known as risk factors for SB, more recent concerns with anti-retroviral drugs have focused attention on the need for continued vigilance at home and abroad. Finally, the impact of fetal surgery to mitigate some of the comorbidities associated with SB are more widely accessible and the opportunity to optimize outcomes is well within our reach.

Robert L. Brent Lecture—Teratogen Update
Everywhere All at Once: The Prenatal Chemical Exposome and Influences on Health and Health Inequities

(Joint with DNTS)
Chairperson: Philip J. Lupo, Baylor College of Medicine
Lecturer: Tracey Woodruff, University of California San Francisco

Lunch and Learn Mini Course
Climate Change: Heat and Wildfires
(Separate Registration Required)
Organized by the Education Committee
Chairperson: Terry C. Hrubec, E. Via Virginia College of Osteopathic Medicine

This course will provide examples of how changes to the climate are affecting fetal development.

New Approaches to Elucidate Contributors to Placental Dysfunction Symposium
Organized by the Science Committee
Chairpersons: Suzanne E. Fenton, NC State University; and
Thomas B. Knudsen, US Environmental Protection Agency (Retired)

The placenta is a critical organ of fetal origin existing only during pregnancy. It serves as the exchange network between the mother and developing fetus, mediating the transfer of nutrients, oxygen, blood, waste, and pharmaceutical and environmental chemicals. Proper development and function of the placenta is critical for fetal growth and the health of the mother. Indeed, many adverse pregnancy outcomes are due to placental insufficiency or dysfunction, a condition during which the placental function is limited or deteriorated, leading to reduced inappropriate transplacental transfer of oxygen and nutrients to the fetus. Placental insufficiency can lead to pre-eclampsia, intrauterine growth retardation, preterm labor, and other adverse outcomes during pregnancy. Pre-eclampsia is on the rise in industrialized countries and may affect 10% of pregnancies, with an even higher percentage in women of color. Toxicological and epidemiological evidence shows that the placenta is vulnerable to environmental insults, but new approaches are needed to advance our knowledge of the mechanisms and critical pathways leading to adverse outcomes. This symposium brings together experts that have developed advances in the models and techniques for studying environmental impacts on placental, as well as novel advances in the pathways that may lead to placental dysfunction and pregnancy complications or effects on the newborn.

BDRP and ETS Exchange Lecture (L2)
Labeling and Communication Risk
Chairpersons: Anthony M. DeLise, Novartis Pharmaceuticals Corporation; and
Jason C. Manton, Toxiqua Ltd.

BDRP
Leyla Sahin, US FDA, CDER

ETS
Helen-Marie Dunmore, Charles River

Developmental Neuropathology in Rodents: Chemicals versus Pediatric Pharmaceuticals Workshop
(Joint with DNTS)
Chairpersons: Prägati S. Coder, Charles River Laboratories, Ashland LLC; and
Lori A. Dostal, LD DART Consulting

Neuropathology evaluation of the brain, central and peripheral nervous system (CNS/PNS) tissues is a key element of developmental neurotoxicology assessments for studies of chemicals as well as certain pharmaceuticals being developed for pediatric patients. However, the extent of assessments required can vary substantially depending upon the nature of the test material and consequent regulatory requirements. Pharmaceuticals intended for young patients may be administered for brief periods during development or chronically through adulthood. The mechanism of action of these products is often well understood and the dose achieved in the brain and CNS/PNS can often be accurately determined depending on the route of administration, treatment duration, and known total dose. In contrast, industrial, agricultural, and environmental chemical doses can vary significantly, and often little is known about the timing and potential cumulative exposure during development. As such, the requirements for sampling, processing, and neuropathological evaluations for these chemical substances may be substantively different. The workshop introduction will present typical guideline studies that require neuropathology and the requirements for expanded neuropathological evaluations in juvenile animal studies for pharmaceuticals versus developmental neurotoxicology studies for chemicals. The three core presentations will present the development of the mammalian nervous system, methods for standard and specialized neuropathology analyses, common test article-related findings and their interpretation (e.g., Olney lesions), and results that may trigger the need for expanded neurohistopathology evaluations such as special neurohistological stains and/or brain morphometry. The session will be followed by a Panel Discussion, with regulatory representatives from the chemical and pharmaceutical areas to help address audience questions pertaining to neuropathology considerations.

Warkany Tea

DART Strategies for Oligonucleotides Symposium
Chairpersons: Bethany R. Hannas, Eli Lilly and Company; and
Michael V. Templin, Charles River Laboratories
Supported by the Health and Environmental Sciences Institute

Annual Meeting Awards Presentation and Business Meeting
Graduate Student and Postdoctoral Fellow Travel Awards
Wilson Presentation Awards
Marie Taubeneck Award
James C. Bradford Memorial Student Poster Awards
Edward W. Carney Trainee Awards
BDRP Innovator Award
Edward W. Carney Distinguished Service Award
Recognition of Other Awards Presented throughout the Week
Annual Business Meeting

Closing Celebration

Council 2 Meeting
(2024–2025 Council members)