Advances in Reproductive and Developmental Toxicity Risk Assessment of Bio-Pharmaceuticals
Organized by the Education Committee: Christopher Lau, Chairperson
Coursebooks provided by Charles River Laboratories, Inc.

7:00 AM-7:45 AM		Regulatory Aspects of Toxicity Testing for Reproductive and Developmental Toxicity
		Speaker: Andrea B. Weir, Charles River Laboratories, Navigators
7:45 AM-8:30 AM		Approaches to Toxicity Testing for Reproductive and Developmental Toxicity
		Speaker: William Breslin, Eli Lilly and Company

 

Epigenetics & Developmental Programming of Metabolic Disorders Symposium
Chairperson: John M. Rogers, U.S. Environmental Protection Agency
Supported in part by March of Dimes Birth Defects Foundation
Grant No. 4-FY06-567

8:30 AM-8:35 AM		Introduction
		Speaker: John M. Rogers, U.S. Environmental Protection Agency
8:35 AM-9:15 AM	S10	Developmental Programming of the Metabolic Syndrome: Evidence in Humans
		Speaker: Keith Godfrey, University of Southampton, U.K.
9:15 AM-9:55 AM	S11	Animal Models of the Metabolic Syndrome: Cardiovascular Effects
		Speaker: Mark Hanson, University of Southampton, U.K.
9:55 AM-10:10 AM		Break
10:10 AM-10:50 AM	S12	Animal Models of the Metabolic Syndrome: Programming of Pancreatic Islets and Obesity
		Speaker: Mulchand S. Patel, State University of New York at Buffalo
10:50 AM-11:30 AM	S13	Epigenetic Transgenerational Effects of Endocrine Disruptors
		Speaker: Matthew D. Anway, Washington State University

 

APPLICATIONS OF HIGH-INFORMATION CONTENT TECHNOLOGY IN REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY
Chairpersons: George P. Daston, Procter & Gamble Company and Thomas B. Knudsen, University of Louisville

 

2:00 PM-2:40 PM	W1	Genomics Approaches to Identify Molecular Responses to Estrogens and Androgens
		Speakers: Jorge Naciff and George P. Daston, Procter & Gamble Company
2:40 PM-3:20 PM	W2	Omics Approaches to Identify a Novel Mechanism of Female Reproductive Toxicity
		Speaker: Kary E. Thompson, Bristol-Myers Squibb Company
3:20 PM-3:40 PM		Break
3:40 PM-4:20 PM	W3	Cheminformatic Approaches in Predictive Toxicology
		Speaker: Ann Richard, U.S. Environmental Protection Agency
4:20 PM-5:00 PM	W4	Systems Biology Approaches in Normal and Abnormal Development
		Speaker: Julia Gohlke, National Institute of Environmental Health Sciences

Mechanisms, Genetic and Environmental Risk Factors
Chairpersons: Jan M. Friedman, University of British Columbia and Elaine Z. Francis,U.S. Environmental Protection Agency

2:00 PM-2:15 PM	24	Gene-Environment Interaction: Impact of Prenatal Tobacco Exposure and the DRD2 Gene on Neonatal Regulation
		Espy KA1, Stopp C1, Huggenvik J2, Jameson T2, Gilbert D2, Stewart P1. 1University of Nebraska-Lincoln, Lincoln, NE, United States, 2Southern Illinois University, Carbondale, IL, United States.
2:15 PM-2:30 PM	25	Effects of Valproic Acid on Gene Expression in the Rhombencephalon of Day 12 Rat Embryos
		Stodgell CJ, Glazko G. University of Rochester, Rochester, NY, United States.
2:30 PM-2:45 PM	26	Pharmacokinetics of Psychotropic Drugs in Pregnancy
		Sit DK, Perel JM, Helsel J, Wisner KL. University of Pittsburgh, Pittsburgh, PA, United States.
2:45 PM-3:00 PM	27	Association Between Antidepressant Use During Pregnancy and Infants Born Small for Gestational Age
		Ramos E1,2, Oraichi D2, Berard A1,2. 1University of Montreal, Montreal, QC, Canada, 2CHU Sainte-Justine, Montreal, QC, Canada.
3:00 PM-3:15 PM	28	Effect of Smoking Cessation Interventions During Pregnancy on the Newborn
		Berard A1,2, Ferreira E1,2, Oraichi D2. 1University of Montreal, Montreal, QC, Canada, 2CHU Ste-Justine, Montreal, QC, Canada.
3:15 PM-3:30 PM		Break

 

Epidemiology and Etiology
Chairpersons: Jan M. Friedman, University of British Columbia and
Elaine Z. Francis, U.S. Environmental Protection Agency

3:30 PM-3:45 PM	29	Maternal Exposure to Statins and Risk for Birth Defects: A Case-Series Approach
		Petersen EE1, Rasmussen SA1, Carey JC2, Mitchell AA3. 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2University of Utah Health Sciences Center, Salt Lake City, UT, United States, 3Slone Epidemiology Center at Boston University, Boston, MA, United States.
3:45 PM-4:00 PM	30	Maternal Prepregnant Obesity and Risks of Selected Birth Defects in Offspring
		Shaw GM, Carmichael SL. March of Dimes, California Birth Defects Monitoring Program, Berkeley, CA, United States.
4:00 PM-4:15 PM	31	Maternal Periconceptional Smoking and Alcohol Consumption and Risk for Select Birth Defects
		Grewal J, Carmichael SL, Shaw GM, Ma C. March of Dimes/California Birth Defects Monitoring Program, Berkeley, CA, United States.
4:15 PM-4:30 PM	32	Residential Mobility During Pregnancy in Atlanta: Patterns and Predictors
		Siffel C1,2, Miller A1, Correa A1. 1CDC, NCBDDD, Atlanta, GA, United States, 2Computer Sciences Corporation, Atlanta, GA, United States.
4:30 PM-4:45 PM	33	Effect of Gestational Use of Hypoglycaemic Agents and Insulin on Adequacy of Maternal Glycaemia Control and Birth Defect Rates in a Population of Type II Diabetes Women
		Berard A1,2, Rey E1,2, Oraichi D2. 1University of Montreal, Montreal, QC, Canada, 2CHU Ste-Justine, Montreal, QC, Canada.
4:45 PM-5:00 PM	34	Sunlight, Neurulation, and the “Madness-Creativity” Nexus
		Marzullo G. Per Aspera Research Foundation, New York, NY, United States.