Molecular Clocks in Embryonic Development Symposium
Chairpersons: Karen A. Augustine, Bristol Myers Squibb Research Institute and
Michael D. Collins, UCLA School of Public Health
Sponsored by John Wiley and Sons, Inc.

8:20 AM-9:00 AM	S14	Notch Signaling in Somitogenesis
		Speaker: Scott Holley, Yale University
9:00 AM-9:40 AM	S15	Real-Time Imaging of the Somite Segmentation Clock
		Speaker: Alexander Aulehla, Stowers Institute for Medical Research

10:10 AM-10:50 AM	S16	Translation of the Temporal Information Provided by the Segmentation Clock
		Speaker: Yumika Saga, National Institute of Genetics, Japan
10:50 AM-11:30 AM	S17	Disruption of the Segmentation Clock and Human Vertebral Anomalies and Scoliosis
		Speaker: Kenro Kusumi, Arizona State University

Chairperson: Lewis B. Holmes, Massachusetts General Hospital for Children
Sponsored by Office of Rare Diseases, National Institutes of Health, DHHS

2:00 PM-2:05 PM		Introduction
		Speaker: Lewis B. Holmes, Massachusetts General Hospital for Children
2:05 PM-2:45 PM	S18	Renal Agenesis: Beyond Potter Syndrome
		Speaker: Patrick D. Brophy, University of Michigan
2:45 PM-3:25 PM	S19	Polydactyly
		Speaker: Leslie Biesecker, National Institutes of Health
3:25 PM-3:40 PM		Break
3:40 PM-4:20 PM	S20	Hypospadias
		Speaker: Jeanne M. Manson, Children's Hospital of Philadelphia
4:20 PM-5:00 PM	S21	Malformations Associated with SALL1-4 Mutations
		Speaker: Jurgen Kohlhase, University of Freiburg

 

New Insight into Reproductive / Developmental Mechanisms
Chairpersons: John M. DeSesso, Noblis and
Mary Alice Smith, University of Georgia

2:00 PM-2:15 PM	35	The Developmental Toxicity of Perfluorooctanoic Acid (PFOA) in the Mouse Requires Expression of Peroxisome Proliferator Activated Receptor-alpha (PPAR)
		Abbott BD, Wolf CJ, Das KP, Schmid JE, Lau CS. RTD/NHEERL/ORD/EPA, Research Triangle Park, NC, United States.
2:15 PM-2:30 PM	36	Developmental Toxicity Associated with Intracellular Protein Tyrosine Kinase Syk Inhibition
		Clemens GR1, Schroeder RE2, Weaver EV3, Lech JW4, Grossbard EB1. 1Rigel Pharmaceuticals, Inc., South San Francisco, CA, United States, 2MPI Research, Inc., Mattawan, MI, United States, 3Covance Laboratories, Inc., Vienna, VA, United States, 4Charles River Laboratories Preclinical Services, Horsham, PA, United States.
2:30 PM-2:45 PM	37	The Inhibition of p38 MAPK Activation Enhances Fetal Mortality Induced by Hydroxyurea (HU) in Organogenesis Stage Mouse Embryos
		Yan J, Hales BF. McGill University, Montreal, QC, Canada.
2:45 PM-3:00 PM	38	The Role of CYP1A2 and the Aryl Hydrocarbon Receptor (AHR) in PCB-induced Developmental Neurotoxicity
		Curran CP1, Williams MT2, Vorhees CV2, Dalton TP1, Nebert DW1. 1University of Cincinnati Medical Center, Cincinnati, OH, United States, 2Cincinnati Children's Research Foundation, Cincinnati, OH, United States.
3:00 PM-3:15 PM	39	A Mutant Allele of the Aryl Hydrocarbon Receptor Protects the Developing Kidney from Hydrocarbon-Induced Deficits in Cellular Differentiation
		Nanez A, Ramos KS. 1University of Louisville, Louisville, KY, United States, 2Center for Genetics and Molecular Medicine, Louisville, KY, United States.
3:15 PM-3:30 PM	40	All-Trans Retinoic Acid-Induced Limb and Lower-Body Duplications: Murine Strain Sensitivities and Potential Mechanisms
		Liao X1, Srinivas S2, Guo F1, Collins M1. 1University of California, Los Angeles, Los Angeles, CA, United States, 2Unviersity of Oxford, London, United Kingdom.
3:30 PM-3:45 PM		Break
3:45 PM-4:00 PM	41	Fetal Ultrasound Measures as Predictors of Alcohol-Related Physical Features in the Newborn: Preliminary Results
		Jones KL1, Hull AD1, Bakhireva LN1, Wertelecki WW2, Yevtushok L3, Sosynyuk Z3, Shevchenko S3, Zharko L3, Onischenko S3, Drapkina I3, Chambers CD1. 1University of California, San Diego, La Jolla, CA, United States, 2University of South Alabama, Mobile, AL, United States, 3OMNI-Net Ukrainian Birth Defects Program, Rivne and Kherson, Ukraine
4:00 PM-4:15 PM	42	Fetal Alcohol Syndrome Detected Through Proteomics Screening of the Amniotic Fluid in High-Risk (B6J) and Low-Risk (B6N) C57BL/6 Mice
		Datta S, Turner D, Singh R, Ruest LB, Pierce, Jr. WM, Knudsen TB. University of Louisville, Louisville, KY, United States.
4:15 PM-4:30 PM	43	Brain Cell Death Induced by a Combination of Inhalation Anesthetics in the Developing Rat and Protection From This Effect by L-carnitine
		Slikker, Jr. W1, Zou X1, Sadovova N2, Divine B2, Hotchkiss C3, Patterson T1, Ali S1, Hanig J4, Paule M1, Wang C1. 1NCTR/FDA, Jefferson, AR, United States, 2Toxicologic Pathology Associates, Jefferson, AR, United States, 3Bionetics, Jefferson, AR, United States, 4CDER/FDA, Rockville, MD, United States.
4:30 PM-4:45 PM	44	Terminal Transverse Limb Defects (TTLD) With Nubbins
		Ghany JF, Westgate MN, Holmes LB. Genetics Unit, MassGeneral Hospital For Children, Boston, MA, United States.
4:45 PM-5:00 PM	45	Anomalous Neural Tube Defects in CD-1 Mice
		Mallela MK1, Hrubec TC1,2. 1Department of Biomedical Sciences and Pathobiology, VA-MD Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States, 2Department of Biomedical Sciences, E. Via Virginia College of Osteopathic Medicine, Blacksburg, VA, United States.