Chairperson: Philip E. Mirkes, Texas A&M University and
Barbara D. Abbott, U.S. Environmental Protection Agency

8:00 AM-8:15 AM	46	A Genomic Approach to Hyperthermia-Induced Neural Tube Defects
		Barrier M, Mo Q, Vannucci M, Mirkes PE. Texas A&M University, College Station, TX, United States.
8:15 AM-8:30 AM	47	Metal-Induced Toxicogenomic Response in Resistant and Sensitive Mouse Strains Undergoing Neurulation
		Robinson JF, Yu X, Griffith WC, Hong S, Beyer RP, Faustman EM. University of Washington, Seattle, WA, United States.
8:30 AM-8:45 AM	48	The Genomic Response of Ishikawa Cells to Chemicals With Estrogenic Activity Supports Their Use as a Potential Alternative to Animal Testing for Estrogens
		Naciff JM, Khambatta ZS, Carr JG, Thomason RG, Reichling TD, Tiesman JP, Daston GP. The Procter and Gamble Company, Cincinnati, OH, United States.
8:45 AM-9:00 AM	49	Differential Programming of p53-Deficient Embryonic Cells During a Rotenone-Block Revealed by mRNA and MicroRNA Profiling
		Singh AV, Green ML, States JC, Knudsen TB. University of Louisville, Louisville, KY, United States.
9:00 AM-9:15 AM	50	Altered Developmental Programming of Fetal Liver by Prenatal Arsenic Exposure Associated With Accelerated Atherogenesis in ApoE-knockout Mice
		States JC1, Singh AV1, Miller HL1, Piao Y2, Ko MSH2, Srivastava S1, Knudsen TB1. 1University of Louisville, Louisville, KY, United States, 2National Institute on Aging, Baltimore, MD, United States.
9:15 AM-9:30 AM	51	Diabetic Embryopathy: Molecular Response of the Embryo and Role of the Placenta
		Kappen CT1,3, Pavlinkova G2, Kruger C1,2, Salbaum JM1,3. 1Pennington Biomedical Research Center/LSU, Barton Rouge, LA, United States, 2University of Nebraska Medical Center, Omaha, NE, United States, 3Munroe-Meyer Institute, Omaha, NE, United States.
9:30 AM-9:45 AM	52	Altered Developmental (Fetal) Programming of the Mouse Mammary Gland in Female Offspring Following Maternal Dietary Exposures
		Singh AV1, Luijten M2, de Vries A2, Piersma AH2, Knudsen TB1. 1University of Louisville, Louisville, KY, United States, 2RIVM, Bilthoven, Netherlands.
9:45 AM-10:00 AM	53	MicroRNA Expression Changes in Response to Hyperthermia During Early Postimplantation Mouse Development
		Barrier M1, Chen YA1, Shelton J2, Dugas DV2,3, Ford LP2, Mirkes PE1. 1Texas A&M University, College Station, TX, United States, 2Applied Biosystems, Austin, TX, United States, 3Rice University, Houson, TX, United States.
10:00 AM-10:15 AM	54	Chromatin, Human Stem Cells, and Tissue Engineering: Shifting Paradigms to Improve Relevancy in Developmental Toxicology Research
		Cho EL1, Li WJ2, Tuan RS2. 1Sciences International, Alexandria, VA, United States, 2NIH/NIAMS/CBOB, Bethesda, MD, United States.

 

Chairpersons: William Slikker, Jr., National Center for Toxicological Research, U.S. Food and Drug Administration and
Charlotte Anne Hobbs, University of Arkansas for Medical Sciences

 

7:30 AM-8:10 AM	S22	The Importance of Personalized Medicine and Nutrition: What it is and Why it is Critical; Barriers and Bridges
		Speaker: Melissa S. Tassinari, Pfizer Inc.
8:10 AM-8:50 AM	S23	Molecular Epidemiological Tool Kit for Personalized Medicine
		Speaker: Charlotte Anne Hobbs, University of Arkansas for Medical Sciences
8:50 AM-9:30 AM	S24	Examples of Associations Between Polymorphisms and Birth Defects: Folic Acid and Retinoic Acid
		Speaker: Deborah K. Hansen, National Center for Toxicological Research, U.S. Food and Drug Administration
9:30 AM-10:10 AM	S25	Susceptibility to the Developmental Neurotoxicity of Anesthetics: Studies on Neuroprotection
		Speaker: William Slikker, Jr., National Center for Toxicological Research, U.S. Food and Drug Administration

Chairperson: Robert L. Brent, AI DuPont Hospital for Children and Thomas Jefferson University

10:30 AM-10:50 AM	W5	Introduction to Achieving Worldwide Elimination of Folic Acid-Preventable Spina Bifida and Anencephaly
		Speaker: Robert L. Brent, AI DuPont Hospital for Children and Thomas Jefferson University
10:50 AM-11:10 AM	W6	Progress Towards Worldwide Prevention of Folic Acid Preventable Spina Bifida
		Speaker: Godfrey P. Oakley, Rollins School of Public Health, Emory University
11:10 AM-11:30 AM	W7	New and Continuing Policy Issues About Optimal Fortification of Flour with Folic Acid and VitaminB12
		Speaker: Gilbert S. Omenn, University of Michigan Medical School
11:30 AM-11:50 AM	W8	Review of Evidence Base for Tolerable Upper Level of Folic Acid
		Speaker: Robert J. Berry, National Center on Birth Defects and Developmental Disabilities, CDC
11:50 AM-12:10 PM	W9	Will Increasing the Level of Folic Acid Fortification of Enriched Flours Further Reduce Neural Tube Defects (NTDs) Without Causing Harm?
		Speaker: Richard B. Johnston, Jr., University of Colorado, School of Medicine
12:10 PM-12:30 PM		Discussion

 

Chairpersons: Donald G. Stump, WIL Research Laboratories, LLC and
Judith W. Henck, Eli Lilly & Company
Sponsored by Midwest Teratology Association

10:30 AM-10:40 AM		Introduction
		Speaker: Donald G. Stump
10:40 AM-11:20 AM	W10	Estrogen Receptor Biology and Current Research Directions
		Speaker: Kenneth S. Korach, National Institute of Environmental Health Sciences
11:20 AM-12:00 PM	W11	Reproductive and Developmental Toxicity of Therapeutic Estrogen Receptor Modulators
		Speaker: Judith W. Henck, Eli Lilly & Company
12:00 PM-12:40 PM	W12	Reproductive and Developmental Toxicity of Phytoestrogens
		Speaker: K. Barry Delclos, National Center for Toxicological Research, U.S. Food and Drug Administration
12:40 PM-1:00 PM		What Does the Future Hold for Estrogen Receptor Modulators?
		Panel Discussion/Audience