TS 2011 Annual Meeting

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Meeting Program

(information subject to change)

Monday, June 27, 2011

7:00 AM–8:00 AM

BDRB Editoral Board Meeting—Aurora

7:00 AM–8:00 AM

Finance Committee Meeting—Britannia

7:00 AM–8:00 AM

Student Affairs Committee Meeting—Cambria

7:00 AM–4:00 PM

Speaker Ready Room Open–Board Room

7:15 AM–8:00 AM

Dine with a Teratology Ambassador

7:30 AM–8:00 AM

Continental Breakfast—Commodore Ballroom C

7:30 AM–7:30 PM

Exhibit Hall Open—Commodore Ballroom C

8:00 AM–6:00 PM

Registration—Commodore Foyer

8:00 AM–9:00 AM

TS/ETS Exchange Lecture—Commodore Ballroom E

All Mixed-Up about Mixtures: How Big of a Problem and What to Do About It?

Chairpersons: Susan Makris and John M. Rogers, U.S. Environmental Protection Agency

Teratology Society

Cumulative Risk Is Readily Managed Using New Tools to Identify Cumulative Exposure of High vs. Low Concern (L4)

Edward W. Carney, The Dow Chemical Company

European Teratology Society

Cumulative Risk Represents a Serious Gap in Current Risk Assessment Requiring Major Changes to Current Practice (L5)

Ulla Hass, National Food Institute, Denmark

9:00 AM–12:00 NOON

TS/NBTS/OTIS Joint Symposium—Commodore Ballroom E

Attention Deficit Hyperactivity Disorder: The Role of Prenatal and Postnatal Environment

Chairpersons: Asher Ornoy, Hebrew University Hadassah Medical School and Susan L. Schantz, University of Illinois

9:00 AM–9:15 AM	S6	Introduction
		James J. McGough, David Geffen School of Medicine
9:15 AM–10:00 AM	S7	Prenatal Cigarette Smoke Exposure and Effects on Offspring Attention, Activity, and ADHD: An Update
		Marie D. Cornelius, University of Pittsburgh
10:00 AM–10:45 AM	S8	Attention Deficit Hyperactivity Disorder (ADHD): The Impact of Intrauterine Exposure to Opiates and Other Substances of Abuse
		Asher Ornoy, Hebrew University Hadassah Medical School
10:45 AM–11:00 AM		Break (In the Exhibit Hall)

11:00 AM–11:45 AM	S9	The Role of Environmental Contaminants in ADHD
		Kimberly Yolton, Cincinnati Children's Hospital Medical Center
11:45 AM–12:00 NOON		Summary/Conclusions
		Susan L. Schantz, University of Illinois

12:00 NOON–1:30 PM

Past Presidents’ and Honorees’ Luncheon—Cambria
(By Invitation Only)

12:00 NOON–1:30 PM

Web Site Committee Meeting—Aurora
(Lunch on Your Own)

12:00 NOON–1:30 PM

Lunch on Your Own

1:30 PM–2:30 PM

State of the Art Lecture—Commodore Ballroom E

Obesogens, Stem Cells and the Maternal Programming of Obesity (L6)

Chairperson: John M. Rogers, U.S. Environmental Protection Agency

Lecturer: Bruce Blumberg, University of California, Irvine

2:30 PM–5:30 PM

Determining the Risk of Environmental Chemicals to Reproduction and Development Symposium—
Commodore Ballroom E

Chairpersons: Robert L. Brent, DuPont Hospital for Children and Thomas Jefferson University and Daland R. Juberg, Dow AgroSciences, LLC

2:30 PM–2:35 PM		Introduction
		Robert L. Brent, DuPont Hospital for Children and Thomas Jefferson University
2:35 PM–3:00 PM	S10	Risk Assessment at the U.S. Environmental Protection Agency
		Rita Schoeny, Office of Water, U.S. EPA
3:00 PM–3:25 PM	S11	The Use of Animal Studies in Assessing Risk for Chemicals: Phthalates and Bisphenol A (BPA)
		Rochelle W. Tyl, RTI International
3:25 PM–3:50 PM	S12	Advancing the Practice of Toxicology in Risk Assessment and Regulatory Decision-Making
		Daland R. Juberg, Dow AgroSciences, LLC
3:50 PM–4:05 PM		Break (In the Exhibit Hall)

4:05 PM–4:30 PM	S13	The Use of Ecological Epidemiology When Evaluating Environmental Chemicals
		Jan M. Friedman, University of British Columbia
4:30 PM–4:55 PM	S14	Use of High-Throughput Testing and Approaches for Evaluating Chemical Risk: Relevance to Humans
		Thomas Knudsen, U.S. Environmental Protection Agency
4:55 PM–5:30 PM		Roundtable Discussion
		Discussion Leader: Robert L. Brent, DuPont Hospital for Children and Thomas Jefferson University

2:30 PM–5:30 PM

TS/OTIS Joint Platform Session II––Constellation A

Clinical Teratology and Epidemiology

Chairpersons: Robert Felix, CTIS, University of California, San Diego and Sonja A. Rasmussen, Centers for Disease Control and Prevention

2:30 PM–2:35 PM		Introduction Robert Felix, CTIS, University of California, San Diego

2:35 PM–2:50 PM	9	Prenatal Alcohol Exposure Pattern and Alcohol-Related Birth Defects and Growth Deficiencies: A Prospective Study Sawada H^1,2, Jones KL¹, Lindsay S², Slymen D², Klonoff-Cohen H¹, Kao K¹, Rao S¹, Chambers C¹. ¹University of California, San Diego, La Jolla, CA, United States, ²San Diego State University, San Diego, CA, United States.

2:50 PM–3:05 PM	10	Fetal Alcohol Spectrum Disorders in Orphanage Children in Brazil: A Multidisciplinary Study Strömland K¹, Ventura LO², Mirzaei L¹, Brandt C², Fontes K², Moura A², Ventura B², Bandim M², Coelho SC², Ivo A². ¹Institute of Neuroscience and Physiology/Ophthalmology, Gothenburg University, Gothenburg, Sweden, ²Department of Pediatric Ophthalmology, Altino Ventura Foundation and Hospital de Olhos de Pernambuco, Pernambuco, Brazil.

3:05 PM–3:20 PM	11	Child Neurodevelopment Following In Utero Exposure to Maternal Azathioprine: Preliminary Results Nulman I^1,2, Barrera M¹. ¹The Hospital for Sick Children, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada.

3:20 PM–3:35 PM	12	Diet Quality and Risks of Neural Tube Defects and Orofacial Clefts Carmichael SL¹, Yang W¹, Feldkamp ML², Munger RG³, Siega-Riz AM⁴, Botto L², Shaw GM¹. ¹Stanford University, Stanford, CA, United States, ²University of Utah, Salt Lake City, UT, United States, ³Utah State University, Logan, UT, United States, ⁴University of North Carolina Gillings School of Public Health, Chapel Hill, NC, United States.

3:35 PM–3:50 PM	13	Maternal Use of Hot Tub and Major Structural Birth Defects Waller DK¹, Duong HT¹, Hashmi SS², Ramadhani T³, Scheuerle A³, Canfield MA³. ¹University of Texas Houston Health Science Center, School of Public Health, Houston, TX, United States, ²University of Texas Houston Health Science Center, Medical School, Houston, TX, United States, ³Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, United States.

3:50 PM–4:05 PM		Break (In the Exhibit Hall)

4:05 PM–4:20 PM	14	Dispensing Patterns and Pregnancy Outcomes in Women Dispensed Proton Pump Inhibitors during Pregnancy Colvin L^1,2, Slack-Smith L², Stanley FJ¹, Bower C^1,3. ¹Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia, ²School of Dentistry, The University of Western Australia, Perth, Western Australia, Australia, ³WA Register of Developmental Anomalies, Perth, Western Australia, Australia.

4:20 PM–4:35 PM	15	Ocular Toxicity in the Offspring of Women Exposed In Utero to Antimalarial Drugs: A Systematic Review of the Literature Osadchy A, Ratnapalan T, Koren G. Motherisk Program, Division of Clinical Pharmacology and Toxicology, Toronto, ON, Canada.

4:35 PM–4:50 PM	16	Using ICD-9 Codes in Discharge Diagnoses to Establish Prevalence of Malformations in Newborn Infants Holmes LB, Westgate M-N. MassGeneral Hospital for Children, Boston, MA, United States.

4:50 PM–5:05 PM	17	Medically Assisted Reproduction (MAR), Including Ovulation Stimulators, and the Risk of Major Congenital Malformations: The AtRISK Study Chaabane SC¹, Sheehy OS¹, Blais LB^1,2, Fraser WF^1,3, Bissonnette FB^1,8, Désilets VD^1,4, Monnier PM^1,6, Tan SLT^1,5, Trasler JT^1,7, Bérard AB¹. ¹Research Center, CHU Ste-Justine University of Montreal, Montreal, QC, Canada, ²Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada, ³Department of Obstetrics and Gynecology, CHU Ste-Justine, Montreal, QC, Canada, ⁴Department of Pediatrics, CHU Ste-Justine, Montreal, QC, Canada, ⁵MUHC University Reproductive Center, Department of Obstetrics and Gynecology, Royal Victoria Hospital, Montreal, QC, Canada, ⁶Faculty of Medicine, McGill University, Montreal, QC, Canada, ⁷Montreal Children's Hospital Research Institute, Montreal, QC, Canada, ⁸OVO Fertility Clinic, CHUM, Montreal, QC, Canada.

5:05 PM–5:20 PM	18	Descriptive Analysis of Cloacal Exstrophy in the International Clearinghouse Feldkamp ML¹, Botto LD¹, Mastroiacovo P², Leocini E², Krikov S¹, Carey JC¹. ¹University of Utah School of Medicine, Salt Lake City, UT, United States, ²Coordinating Centre of the International Clearinghouse for Birth Defects Surveillance and Research, Rome, Italy.

5:20 PM–5:30 PM		Discussion Sonja A. Rasmussen, Centers for Disease Control and Prevention

5:30 PM–7:30 PM

TS/NBTS/OTIS Joint Poster Session I and Exhibits Open—Commodore Ballroom C

Click Here to Browse Posters

P1
Mirzaei L¹, Ventura LO², Strömland K¹, Brandt C², Fontes K², Moura A², Ventura B², Bandim M², Coelho SC², Ivo A². ¹Institute of Neuroscience and Physiology/Ophthalmology, Gothenburg University, Gothenburg, Sweden, ²Department of Pediatric Ophthalmology, Altino Ventura Foundation and Hospital de Olhos de Pernambuco, Pernambuco, Brazil. Fetal Alcohol Spectrum Disorders in Children Adopted from Brazil and Eastern Europe

P2
Rocheleau CM¹, Lawson CC¹, Waters MA¹, Hein MJ¹, Stewart PA², Correa A³, Echeverria D⁴, Reefhuis J³. ¹CDC National Institute for Occupational Safety and Health, Cincinnati, OH, United States, ²Stewart Exposure Assssments, LLC, Arlington, VA, United States, ³CDC National Center for Birth Defects and Developmental Disabilities, Atlanta, GA, United States, ⁴Battelle CPHRE, Seattle, WA, United States. Inter-Rater Reliability of Assessed Prenatal Maternal Occupational Exposures to Solvents, Polycyclic Aromatic Hydrocarbons, and Heavy Metals

P3
Lin S¹, Kielb CL¹, Herdt-Losavio ML¹, Bell EM², Chapman BR³, Rocheleau CM⁴, Waters MA⁴, Lawton CC⁴, Stewart PA⁵, Romitti PA⁶, Druschel CM¹. ¹NYS Dept. of Health, Troy, NY, United States, ²University at Albany, Rensselaer, NY, United States, ³Upstate Medical University, SUNY, Syracuse, NY, United States, ⁴NIOSH, Cincinnati, OH, United States, ⁵Stewart Exposure Assessments, LLC, Arlington, VA, United States, ⁶University of Iowa, Iowa City, IA, United States. Maternal Occupational Exposure to Pesticides and the Risk of Musculoskeletal Birth Defects: A Preliminary Analysis

P4
Browne ML^1,2, Caton AR^1,2, Botto LD³, Louik C⁴, Richardson S¹, Druschel CM^1,2. ¹New York State Department of Health, Troy, NY, United States, ²University at Albany School of Public Health, Rensselaer, NY, United States, ³Division of Medical Genetics, Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, UT, United States, ⁴Slone Epidemiology Center at Boston University, Boston, MA, United States. Maternal Butalbital Use and Selected Defects in the National Birth Defects Prevention Study

P5
Bérard A^1,2, Karam F^1,2, Sheehy O², Huneau MC², Blais L^1,3, Briggs G⁴, Roth M⁵, Chambers C⁶, Einarson A⁷, Gaedigk A⁸, Riordan SH⁹, Johnson D¹⁰, Kao K⁶, Koren G⁷, Martin BZ¹¹, Polifka JE¹², Voyer-Lavigne S¹³, Wolfe L¹⁴. ¹Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada, ²Research Center, CHU Ste-Justine, Montreal, QC, Canada, ³Research Center, Sacre-Coeur Hospital, Montreal, QC, Canada, ⁴Outpatient Clinics, Miller Children's Hospital, , Long Beach, CA, United States, ⁵Pregnancy Risk Network, NYS Teratogen Information Service, Binghamton, NY, United States, ⁶Department of Pediatrics, University of California San Diego, La Jolla, CA, United States, ⁷The Motherisk Program, Toronto, ON, Canada,⁸Children's Mercy Hospital & Clinics, Kansas City, MO, United States, ⁹College of Pharmacy, University of Arizona, AZ, United States, ¹⁰California TIS, San Diego, CA, United States, ¹¹Department of Pharmacy, CHU Ste-Justine, Montreal, QC, Canada, ¹²Department of Pediatrics, University of Washington, Seattle, WA, United States, ¹³Connecticut Pregnancy Exposure Information Service, University of Connecticut Health Center, Farmington, CT, United States, ¹⁴Texas TIS, University of North Texas, Denton, TX, United States. Relapse of Depressive and Anxiety Symptoms and Quality-of-Life in Pregnant Users and Discontinued Users of Antidepressants: Results from the OTIS Antidepressants Study

P6
Berard A^1,2, Sheehy O², Kori S³. ¹University of Montreal, Montreal, QC, Canada, ²CHU Ste-Justine, Montreal, QC, Canada, ³MAP Pharmaceuticals Inc., Mountain View, CA, United States. Dihydroergotamine (DHE) Use during Gestation and the Risk of Adverse Pregnancy Outcomes

P7
Cossette B¹, Forget A¹, Beauchesne M-F¹, Lemière C¹, Larrivée P², Blais L¹. ¹Université de Montréal, Montréal, QC, Canada, ²Université de Sherbrooke, Sherbrooke, QC, Canada. Use of Inhaled Corticosteroids or Long-Acting β2-Agonists and the Risk of Preterm Birth and Low-Birth Weight among Pregnant Women with Asthma

P7A
Blais L, Kettani F, Forget A. Univeristé de Montréal, Montréal, QC, Canada. Impact of Maternal Asthma, Its Severity and Control, on the Risk of Spontaneous Abortions

P8
Mutchinick OM, Luna L, Arteaga J, RYVEMCE Collaborative Group. Instituto Nacional de Ciencias, Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico. Increasing at Birth Prevalence of Isolated Gastroschisis and Associated Risk Factors

P9
Thomas EG^1,2, Westgate M-N^1,2, Holmes LB^1,2. ¹Massachusetts General Hospital, Boston, MA, United States, ²Brigham and Women's Hospital, Boston, MA, United States. The Effect of Elective Terminations for Fetal Anomalies on Spectrum of Birth Defects in Liveborn Infants

P10
Ng EW, Chiruvolu P, Levy GF, Allan BR, Wyszynski DF. Amgen Inc., Thousand Oaks, CA, United States. Contraception Language in Informed Consent Forms: A Survey of Biopharmaceutical Companies

P11
Campbell MA¹, Dunn A¹, Wu KL², Roth L³, Donald JM². ¹Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA, United States, ²Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Sacramento, CA, United States, ³Asthma Genetics Lab, University of California, San Francisco, San Francisco, CA, United States. The Developmental Toxicity of Hexavalent Chromium: A Review

P12
Breslin WJ. Lilly Research Laboratories, Corporate Center, Indianapolis, IN, United States. Lack of Adverse Reproductive and Developmental Effects in Rats and Rabbits With LY2196044, a Pan Opioid Receptor Antagonist for the Treatment of Alcohol Use Disorders

P13
Day W¹, Yee S¹, Peterson C¹, Koren G². ¹Vivus Inc, Mountain View, CA, United States, ²Hospital For Sick Children, University Of Toronto, Toronto, ON, Canada. Assessment of the Teratogenic Risk in Fetuses Exposed to Topiramate In Utero

P14
Sköld AC¹, Danielsson C², Brask J³, Salari S³, Stockling K¹, Andersson A², Jalkesten E¹, Grebius M¹, Larsson M¹, Lindström A¹, Blomgren B¹, Pehrson R¹, Danielsson B⁴, Hellmold H¹, Sylvén C², Elinder F³. ¹AstraZeneca R&D Södertälje, Södertälje, Sweden, ²Karolinska Institutet, Stockholm, Sweden, ³Dept Clin & Exp Medicine, Linköping University, Linköping, Sweden, ⁴Pharmanet Development Group, Stockholm, Sweden. Translational Research: Electrophysiological Development in the Embryonic Heart of Rats, Rabbits, and Humans

P15
Kimmel CA¹, Garry MR², DeSesso JM³. ¹Exponent, Inc, Southern Shores, NC, United States, ²Exponent, Inc, Bellevue, WA, United States, ³Exponent, Inc, Alexandria, VA, United States. Relationship between Bent Long Bones, Bent Scapulae and Wavy Ribs: Malformations or Variations?

P16
Ngalame NO, Srivastava S, States JC. University of Louisville, Louisville, KY, United States. Dose Response Effects of In Utero Arsenic Exposure on Atherosclerotic Lesion Formation and Inflammation in ApoE-/- Mice

P17
Prater MR^1,2, Oest ME³, Bahamonde J², Brenseke B². ¹Edward Via College of Osteopathic Medicine, Blacksburg, VA, United States, ²VA-MD Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States, ³SUNY Upstate Medical University, Syracuse, NY, United States. Fetal Programming of Osteoporosis in C57Bl/6 Mice

P18
Carruthers CM¹, Thakur A², Chen H², Stitcher B², White TEK², Ivett J². ¹Forest Research Institute, Jersey City, NJ, United States, ²Covance Laboratories Inc., Vienna, VA, United States. Rat Fetal Pathology Concordance Study

P19
Singh AV¹, Shah I², Sipes NS², Reif D², Knudsen TB². ¹Lockheed Martin, Research Triangle Park, NC, United States, ²National Center for Computational Toxicology, US EPA Office of Research and Development, Research Triangle Park, NC, United States. Chemical Prioritization for Developmental Toxicity Using Literature Mining-Based Weighting of Toxcast^TM Assays

P20
Mylchreest E, Daniels KK. Southern Research, Birmingham, AL, United States. Comparison of the Reproductive Performance of the Harlan and Charles River Sprague-Dawley Rat

P21
Manzano H¹, Hueza IM², Maruo VM³, Górniak SL¹. ¹Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, Universidade de São Paulo, São Paulo, Brazil, ²Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Diadema, Brazil, ³Faculdade Federal do Tocantins, Araguaiana, Tocantins, Brazil. Toxicity of Cyanide in Swine: Evaluation of Postnatal Effects

P22
Cappon GD, Grantham L, Bowman CJ, Chmielewski G, Hurtt ME. Pfizer Global Research & Development, Groton, CT, United States. Power Analysis of Learning and Memory Data Obtained in a Non-Human Primate (NHP) ePPND Study

P23
Islam A, Reig D, Panaitescu E, Ma Z, AbdElmoula M, Menon L. Northeastern University, Boston, MA, United States. Gold-Film Device for In Vitro Recording of Neuronal Signals from E18 Rat Hippocampal Neurons

P24
Kapron CM, Liu J. Trent University, Peterborough, ON, Canada. Cadmium-Induced Activation of JNK, but Not p38 or ERK1/2, in Mouse Embryonic Midbrain Cells in Micromass Culture

P25
Ricci EL^1,3, Paiva AS¹, Eluf BP², Sandini TM³, Udo MSB³, Spinosa HS³, Bernardi MM^2,1. ¹Mackenzie University, São Paulo, SP, Brazil, ²Paulista University, São Paulo, SP, Brazil, ³São Paulo University, São Paulo, SP, Brazil. Prenatal Exposure to Glyphosate on Behavioral and Physical Development in Rats Offspring

P26
Lippi LL¹, Cunha LC¹, Hueza IM², Górniak SL¹. ¹Dept. of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulol SP, Brazil, ²Instituto de Ciências Ambientais, Químicas e Farmacêuticas – Universidade Federal de São Paulo, Diadema, SP, Brazil. Evaluation of Effects of Perinatal Exposure to Ipomoea carnea in Wistar Rats

7:30 PM–9:30 PM

TS/MARTA Student Career Event—Cambria