8:00 AM–8:15 AM

Introduction

8:15 AM–8:30 AM

U.S. EPA's Research Program on Endocrine Disruptors: 15 Years of Advancing Scientific Knowledge
Francis EZ. U.S. Environmental Protection Agency, Office of Research and Development, Washington, DC, United States.

8:30 AM–8:45 AM

Metabolomic Analysis of Human Embryonic Stem Cell Derived Germ Like Cells Following Exposure to Endocrine Active Compounds (EACs)
Henderson WM¹, West FD^2,3, Yang JY^2,3, Stice SL^2,3, Smith MA⁴. ¹National Exposure Research Laboratory, U.S. Environmental Protection Agency, Athens, GA, United States, ²Department of Animal and Dairy Science, University of Georgia, Athens, GA, United States, ³Regenerative Bioscience Center, University of Georgia, Athens, GA, United States, ⁴College of Public Health, Environmental Health Sciences Department, University of Georgia, Athens, GA, United States.

8:45 AM–9:00 AM

Toxicogenomic Response to Valproic Acid and Valproic Acid Analogs in Human Embryonic Stem Cells
Jergil M¹, Strehl R², Salter H³, Dencker L¹, Hyllner J², Stigson M¹. ¹Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden, ²Cellartis AB, Göteborg, Sweden, ³The Linneaus Center for Bioinformatics, Uppsala University, Uppsala, Sweden.

9:15 AM–9:30 AM

The Embryonic Epigenome As Target for Adverse Maternal Metabolism
Salbaum JM, Kappen C. Pennington Biomedical Research Center, Baton Rouge, LA, United States.

9:30 AM–9:45 AM

Molecular Changes Induced by the Teratogenic Environment of Maternal Diabetes in Embryonic Hearts
Pavlinkova G¹, Bohuslavova R¹, Kuthanova L¹, Sedmera D², Bloudickova S¹. ¹Institute of Biotechnology AS CR, Prague, Czech Republic, ²Institute of Physiology AS CR, Prague, Czech Republic.

9:45 AM–10:00 AM

Gestational Exposure to Low Doses of Perfluorooctanoic Acid Increases Adiposity, but Not Body Weight, of Adult Offspring
Grey B, Das K, Grace C, Tatum K, Lau C, Rogers J. TAD/NHEERL/ORD/U.S. EPA, Durham, NC, United States.

Hirschsprung's Disease and Variants in Genes That Regulate Enteric Neural Crest Cell Proliferation and Migration
Carter TC¹, Kay DM², Liu A¹, Browne ML^3,4, Romitti PA⁵, Kuehn D¹, Conley MR¹, Caggana M², Druschel CM^3,4, Brody LC⁶, Mills JL¹. ¹Division of Epidemiology, Statistics, and Prevention Research, NICHD, NIH, Bethesda, MD, United States, ²Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY, United States, ³Congenital Malformation Registry, New York State Department of Health, Albany, NY, United States, ⁴Department of Epidemiology and Biostatistics, University at Albany–State University of New York, Albany, NY, United States, ⁵Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, United States, ⁶Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD, United States.

1:15 PM–1:30 PM

Introduction

1:30 PM–1:45 PM

Developmental Immunotoxicity in Male Rats after Juvenile Exposure to Di-octyltin Dichloride
Tonk ECM^1,2, Verhoef A¹, de la Fonteyne LJJ¹, van Loveren H^1,2, Piersma AH^1,3. ¹National Institute for Public Health and the Environment, Bilthoven, Netherlands, ²Maastricht University, Maastricht, Netherlands, ³Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.

1:45 PM–2:00 PM

Hypoxia Inducible Factor 2α (HIF2α) Induction in Murine Forelimbs Is an Early Response to Exposure In Vitro to a DNA Damaging Teratogen, 4-Hydroperoxycyclophoshpamide
Huang C, Hales BF. McGill University, Montreal, QC, Canada.

2:00 PM–2:15 PM

2:15 PM–2:30 PM

Activation of Phospho-MEK3/6, the MAP2K Upstream of p38 Mitogen-Activated Protein Kinase (p38 MAPK), in Embryos Exposed to the Developmental Toxicant Hydroxyurea
Banh S, Hales BF. McGill University, Montreal, QC, Canada.

2:30 PM–2:45 PM

Break (Commodore Foyer)

2:45 PM–3:00 PM

Is Cardiac Arrhythmia in the Human Embryo a Possible Mechanism for Cardiovascular Defects by IKr Blocking Antidepressants?
Danielsson C¹, Brask J³, Sköld A-C², Andersson A¹, Pehrson R², Stockling K², Elinder F³, Hellmold H², Sylvén C¹, Danielsson BR⁴. ¹Karolinska Institutet, Dept. of Cardiology, Stockholm, Sweden, ²AstraZeneca R&D, Södertälje, Sweden, ³Linköping University, Dept. Clinical and Experimental Medicine, Linköping, Sweden, ⁴Pharmanet Development, Stockholm, Sweden.

Use of Ovulation Stimulation (OS) Alone, Intrauterine Insemination (IUI) and Assisted Reproductive Techniques (ART) and the Risk of Multiplicity: The TWINPREG Study
Bérard A^1,2, Sheehy O¹, Fraser W^3,4, Bissonnette F^4,5, Tan SL^6,7, Trasler J^7,8, Monnier P^6,7. ¹Research Center, CHU Ste-Justine, Montreal, QC, Canada, ²Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada, ³Department of Obstetrics and Gynecology, CHU Ste-Justine, Montreal, QC, Canada, ⁴Faculty of Medicine, University of Montreal, Montreal, QC, Canada, ⁵OVO Fertility Clinic, Saint-Luc Hospital, Montreal, QC, Canada, ⁶MUHC Reproductive Center, Royal Victoria Hospital, McGill University, Montreal, QC, Canada, ⁷Faculty of Medicine, McGill University, Montreal, QC, Canada, ⁸Montreal Children's Hospital Research Institute, Montreal, QC, Canada.