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Annual Meeting 2014

Meeting Program

(Information is subject to change.)

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Wednesday, July 2, 2014



6:30 AM–7:30 AM Society for Birth Defects Research and Prevention 33RD ANNUAL VOLLEYBALL GAME – Tyee Community Gym
7:00 AM–4:30 PM REGISTRATION – Grand Ballroom Foyer
7:00 AM–4:30 PM

SPEAKER READY ROOM OPEN – Grand Ballroom Foyer

  Teratology and Public Health: Working Together to Make Recommendations for Pregnant Women in the Face of Uncertainty (L8)
  Chairperson: Mary Alice Smith, University of Georgia
  Lecturer: Sonja A. Rasmussen, Centers for Disease Control and Prevention

8:30 AM–11:45 PM


  From Fleas to Fish and Beyond: Advances in Alternative Assays to Predict Developmental Toxicity


Chairpersons: Robert G. Ellis-Hutchings and Bethany R. Hannas, The Dow Chemical Company and E. Sid Hunter III, US Environmental Protection Agency

8:30 AM–8:40 AM   Introduction
8:40 AM–9:10 AM S24 Prediction of Developmental Toxicity Using Mouse Embryonic Stem Cells on Environmental Chemicals
    E. Sid Hunter III, US Environmental Protection Agency
9:10 AM–9:40 AM S25 Daphnia as a Whole-Animal Invertebrate Model System for Human Health Research
    Julia M. Gohlke, University of Alabama, Birmingham
9:40 AM–10:25 AM   Warkany Tea
10:25 AM–10:55 AM S27 Using Embryonic Zebrafish and Multidimensional Screening to Evaluate Neurobehavioral Toxicity and Teratology
    Robert Tanguay, Oregon State University
10:55 AM–11:25 AM S28 Applications of Multiple Developmental Toxicology Assays for Teratogenic Hazard Identification and Mechanistic Evaluation
    Karen A. Augustine, Bristol Myers Squibb Research Institute
11:25 AM–11:45 AM   Discussion

12:15 PM–1:30 PM

12:15 PM–1:30 PM BDRA EDITORIAL BOARD MEETING – Evergreen Ballroom G
12:15 PM–1:30 PM EDUCATION COMMITTEE MEETING – Evergreen Ballroom H

1:30 PM–4:30 PM


  Thrombosis during Pregnancy: Risks, Prevention and Treatment for Mother and Fetus

Chairpersons: Emmanuel Fadiran, Office of Women's Health, US FDA and Evi Struble, Center for Biologics Evaluation and Research, US FDA

  Organized by the Public Affairs Committee
1:30 PM–1:45 PM S29 Thrombosis: Molecular Mechanisms, Clinical Picture, and Treatment Options during Pregnancy: An Introduction
    Lisa Soule and Evi Struble, US Food and Drug Administration
1:45 PM–2:20 PM S30 Thrombosis in Pregnancy and Maternal Outcomes
    Andra H. James, University of Virginia
2:20 PM–2:55 PM S31 Thrombophilia in Pregnancy and Fetal Outcome: Special Emphasis on Antiphospholipid Syndrome (APLS)
    Sarah Gloria Obican, Columbia University and
Asher Ornoy, Israel Ministry of Health and Hebrew University
2:55 PM–3:10 PM   Break
3:10 PM–3:45 PM S32 Management of Thrombosis in Pregnancy
    Barbara Konkle, Puget Sound Blood Center
3:45 PM–4:20 PM S33 Harvesting the Power of `Omic Technology, Biomarkers and In Vitro or In Vivo Models to Facilitate the Treatment of Thrombosis
    Michael Paidas, Yale University
4:20 PM–4:30 PM   Panel Discussion and Closing Remarks
    Evi Struble, Center for Biologics Evaluation and Research, US FDA
1:30 PM–4:30 PM PLATFORM SESSION 5 – Grand Ballroom A
  In Vitro, Stem Cells, and Alternative Approaches

Chairpersons: : Kimberly Brannen, Charles River Laboratories and Deborah K. Hansen, US Food and Drug Administration

1:30 PM–1:45 PM   Introduction
1:45 PM–2:00 PM 35 Propofol-Induced Toxicity in Embryonic Neural Stem Cells and the Potential Protective Effect of Acetyl-L-Carnitine

Slikker Jr. W, Liu F, Rainoseck SW, Sadovova N, Fogle CM, Patterson TA, Hanig JP, Paule MG, Wang C. US Food and Drug Administration, NCTR, Jefferson, AR, United States.

2:00 PM–2:15 PM 36 Effect of Growth Factors on Stem Cell Transplantation in Rat Fetuses with Spina Bifida Aperta
    Yuan Z, Li H, Cao S, Gu H. Shengjing Hospital, China Medical University, Shenyang, China.
2:15 PM–2:30 PM 37 Short-Term Embryonic Stem Cell Exposure Assay As a Tool to Predict Developmental Toxicity

Sun Y2, Jergil M1, Stockling K3, Hellmold H3, Dencker L1, Gustafson A-L3, Salter H2, Stigson M1. 1Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden, 2AstraZeneca Translational Science Centre at the Karolinska Institutet, Solna, Sweden, 3AstraZeneca Global Safety Assessment, AstraZeneca R&D, Södertälje, Sweden.

2:30 PM–2:45 PM 38 Using Human Pluripotent Cells to Detect Teratogens and Study Teratogenic Mechanisms
    Flamier A1, Rasmussen T1,2,3. 1University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT, United States, 2University Connecticut Stem Cell Institute, Farmington, CT, United States, 3University Connecticut Institute for Systems Genomics, Storrs, CT, United States.
2:45 PM–3:00 PM 39 Pathway Dynamics of an Organotypic In Vitro Testicular Model Reflect Developmental Processes In Vivo
    Wegner S, Harris S, Stanaway I, Pacheco S, Park J, Hong S, Faustman EM. University of Washington, Seattle, WA, United States.
3:00 PM–3:15 PM   Break
3:15 PM–3:30 PM 40 An In Vitro Assay As a Screening Tool for Listeria monocytogenes Invasion in Maternal and Fetal Tissues
    Wadhwa DR, Amosu M, Smith MA. University of Georgia, Athens, GA, United States.
3:30 PM–3:45 PM 41 The Effects of Carbamazepine and Valproic Acid on Gene Expression in a Human Embryonic Stem Cell Based Assay for Neuro-Developmental Toxicity
    Schulpen SHW1,2, de la Fonteyne LJJ1, de Klerk A1, Piersma AH1,2. 1Centre for Health Effects Research, RIVM, Bilthoven, Netherlands, 2Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.
3:45 PM–4:00 PM 42 The Effects of the Zebrafish Chorion on the Response to Exogenous Chemicals
    Gurrola-Gal MC1, Penney LC2, MacDougall J2, Clipston AS2, Brannen KC1. 1Preclinical Services, Charles River Laboratories, Horsham, PA, United States, 2Preclinical Services, Charles River Laboratories, Tranent, Edinburgh, United Kingdom.
4:00 PM–4:15 PM 43 Presence of Macrophages in an In Vitro Testicular Coculture Model of Male Reproductive Development Enhances Relevance to In Vivo Conditions

Pacheco SE, Wegner S, Green F, Harris S, Faustman EM. University of Washington, Seattle, WA, United States.

4:15 PM–4:30 PM 44 A Novel Human Embryoid Body System (hEB) with Potential to Be Used for Screening Drug Candidates in the Field of Reproductive Toxicology

Allison T1, Powles-Glover NS2, Stewart J2, Andrews PW1. 1The University of Sheffield, Sheffield, Yorkshire, United Kingdom, 2AstraZeneca, DSM, Mereside, Alderley Edge, Cheshire, United Kingdom.

4:45 PM–6:15 PM BUSINESS MEETING – Grand Ballroom E
6:30 PM–7:30 PM BANQUET RECEPTION – Evergreen Ballroom Foyer
7:30 PM–11:00 PM BANQUET – Evergreen Ballroom


Travel Awards
James C. Bradford Memorial Student Poster Awards
Wilson Presentation Awards
Marie W. Taubeneck Award
Birth Defects Research Distinguished Scholar Awards
Distinguished Service Award
Recognition of Other Awards Presented Throughout the Week





Rev. Friday, September 27, 2019; at 11:15:49 AM EDT
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