Program

Meeting Agenda

Society for Birth Defects Research and Prevention 2022 Annual Meeting—From Bench to Bedside and Back Again

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Please note that The times listed are in PDT – Pacific Daylight Time (US).

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9:00 AM–10:30 AM


9:00 AM–10:30 AM


3:00 PM–6:00 PM


7:30 AM–6:00 PM


8:00 AM–8:30 AM


8:30 AM–12:00 Noon

Organized by the Education Committee,
Chairperson: Katie J. Turner, Janssen R&D, LLC



8:30 AM–8:40 AM


8:40 AM–8:45 AM
8:45 AM–9:30 AM


9:30 AM–10:15 AM


10:15 AM–10:30 AM


10:30 AM–11:15 AM


11:15 AM–12:00 Noon


12:00 Noon–1:30 PM


1:30 PM–5:00 PM

Organized by the Education Committee
Chairperson: Katie J. Turner, Janssen R&D, LLC



1:30 PM–1:35 PM


1:35 PM–2:25 PM


2:25 PM–3:15 PM


3:15 PM–3:30 PM


3:30 PM–4:15 PM


4:15 PM–5:00 PM


5:00 PM–7:00 PM


7:00 AM–6:00 PM


7:00 AM–8:00 AM


7:30 AM–8:00 AM


8:00 AM–8:15 AM


8:15 AM–9:00 AM


9:05 AM–12:05 PM





9:05 AM–9:10 AM


9:10 AM–9:30 AM
1


9:30 AM–9:50 AM
2


9:50 AM–10:10 AM
3


10:10 AM–10:30 AM
4


10:30 AM–10:45 AM


10:45 AM–11:05 AM
5


11:05 AM–11:25 AM
6


11:25 AM–11:45 PM
7


11:45 PM–12:05 PM
8

12:05 PM–1:30 PM


12:05 PM–1:30 PM


12:30 PM–1:30 PM


12:30 PM–1:30 PM


1:30 PM–2:00 PM


2:00 PM–2:30 PM


2:35 PM–4:30 PM



2:35 PM–2:40 PM


2:40 PM–3:05 PM
S1


3:05 PM–3:30 PM
S2


3:30 PM–3:45 PM


3:45 PM–4:05 PM
S3


4:05 PM–4:30 PM
S4


4:35 PM–5:35 PM


4:35 PM–4:55 PM
9


4:55 PM-5:15 PM
10


5:15 PM-5:35 PM
11


5:40 PM–6:10 PM


6:15 PM–7:45 PM


P1

Christensen K1, Lehmann G2, Meeker J3, Yost EE2. 1US Environmental Protection Agency, Washington, DC, United States, 2US Environmental Protection Agency, Research Triangle Park, NC, United States, 3University of Michigan, School of Public Health, Ann Arbor, MI, United States. Considerations for the Critical Appraisal of Epidemiology Studies on the Developmental Toxicity of PCBs

P2

Martin-Giacalone BA1, Lin AE2, Kirby RS3, Nestoridi E4, Liberman RF4, Rasmussen SA5,6, Nembhard WN7, Agopian AJ8, Carey JC9, Cragan JD10, Leedom V6, Nance A11, Piccardi M12, Sandidge T13, Shan X14, Shumate C15, Stallings EB10, Stevenson R16, Lupo PJ1. 1Baylor College of Medicine, Houston, TX, United States, 2Massachusetts General Hospital for Children, Boston, MA, United States, 3University of South Florida, Tampa, FL, United States, 4Massachusetts Department of Public Health, Boston, MA, United States, 5University of Florida College of Medicine, Gainesville, FL, United States, 6South Carolina Department of Health and Environmental Control, Columbia, SC, United States, 7University of Arkansas for Medical Sciences, Little Rock, AR, United States, 8University of Texas Health Science Center School of Public Health, Houston, TX, United States, 9University of Utah Health, Salt Lake City, UT, United States, 10National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States, 11Utah Department of Health, Salt Lake City, UT, United States, 12Maryland Department of Health, Baltimore, MD, United States, 13Illinois Department of Public Health, Springfield, IL, United States, 14Arkansas Children's Research Institute, Little Rock, AR, United States, 15Texas Department of State Health Services, Austin, TX, United States, 16Greenwood Genetic Center, Greenwood, SC, United States. Prevalence and Descriptive Epidemiology of Turner Syndrome in the United States: A Report from the National Birth Defects Prevention Network (NBDPN)

P3

Fisher SC1, Howley MM1, Tran EL2,3, Ailes EC3, Papadopoulos EA1, Nembhard WN4, Browne ML1,5. 1Birth Defects Registry, New York State Department of Health, Albany, NY, United States, 2Eagle Global Scientific LLC, San Antonio, TX, United States, 3Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States, 4Department of Epidemiology, University of Arkansas for Medical Sciences, Little Rock, AR, United States, 5Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, Rensselaer, NY, United States. Maternal Cyclobenzaprine Exposure and Risk of Birth Defects in the National Birth Defects Prevention Study (1997–2011) and Birth Defects Study to Evaluate Pregnancy Exposures (2014–2018)

P4

Bedard T1, Thomas MA2, Lowry RB2, Grevers X1, Crawford S3. 1The Alberta Congenital Anomalies Surveillance System, Clinical Genetics, Alberta Children's Hospital, Calgary, AB, Canada, 2Department of Medical Genetics, University of Calgary, Alberta Children's Hospital, Calgary, AB, Canada, 3Alberta Perinatal Health Program, Alberta Health Services, Calgary, AB, Canada. Descriptive Epidemiology of 63 Cases with Oculo-Auriculo-Vertebral Spectrum, from the Alberta Congenital Anomalies Surveillance System, 1997–2019

P5

Woodhouse JP1, Benjamin RH2, Agopian AJ2, Langlois PH3, Canfield MA4, Lupo PJ1, Schraw JM1. 1Pediatrics, Baylor College of Medicine, Houston, TX, United States, 2UTHealth School of Public Health, Houston, TX, United States, 3University of Texas UTHealth School of Public Health, Austin, TX, United States, 4Texas Department of State Health Services, Birth Defects Epidemiology and Surveillance Branch, Austin, TX, United States. Parental and Infant Factors Associated with Nonsyndromic Anotia-Microtia, Texas, 1999–2014

P6

Shumate C1, Agopian AJ2, Salemi J3, Le M1, Arena F1, Canfield MA1. 1Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health and Human Services, Austin, TX, United States, 2Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX, United States, 3University of South Florida College of Public Health, Tampa, FL, United States. The Contribution of Outpatient Hospital Discharge Data for Hypospadias Case Finding and Completeness

P7

Betancourt D, Canfield MA, Kubenka C, Childers-Dykes A, Shumate C, Drummond-Borg M. Texas Department of State Health Services, Birth Defects Epidemiology and Surveillance Branch, Austin, TX, United States. Pilot to Refer Older Children from the Texas Birth Defects Registry to Agency Social Workers for Assistance in Accessing Health and Social Services

P8

Goodman CV1, Till C1, Arbuckle T2, Green R1, Hornung R3, Lanphear B4, Séguin J5, Booij L5, Fisher M2, Muckle G6, Bouchard M5, Ashley-Martin J2. 1York University, Toronto, ON, Canada, 2Health Canada, Ottawa, ON, Canada, 3Cincinnati Children's Hospital Medical Center (Retired), Cincinnati, OH, United States, 4Simon Fraser University, Vancouver, BC, Canada, 5University of Montreal, Montreal, QB, Canada, 6Laval University, Quebec City, QB, Canada. Prenatal PFAS Exposure and IQ in Preschool-Aged Canadian Children: The MIREC Cohort

P9

Aboulatta L1, Kowalec K1,2, Leong C1,3, Delaney J1,4, Falk J1, Alessi-Severini S1,5, Eltonsy S1,6. 1College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada, 2Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, 3Department of Psychiatry, College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada, 4Department of Epidemiology, University of Washington, Seattle, WA, United States, 5Manitoba Centre for Health Policy, Winnipeg, MB, Canada, 6The Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. Impact of COVID-19 Pandemic on Preterm Birth and Stillbirth Rates in Manitoba, Canada: A Quasi-Experimental Study

P10

Desrochers B, Lavu A, Valencia E, Vaccaro C, Eltonsy S. College of Pharmacy, University of Manitoba, Winnipeg, MB, Canada. Adverse Fetal Outcomes Associated with Gabapentin Use in Pregnancy: A Cohort Study and Meta-Analysis

P11

Abstract Withdrawn

P12

Kancherla V1, Wagh K1, Priyadarshini P2, Pachón H2,3, Oakley Jr. GP1. 1Center for Spina Bifida Prevention, Department of Epidemiology, Emory University Rollins School of Public Health University, Atlanta, GA, United States, 2Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States, 3Food Fortification Initiative, Atlanta, GA, United States. The Global Status of Folic Acid-Preventable Spina Bifida and Anencephaly in the Year 2020: 30-Year Anniversary of Gaining Knowledge about Folic Acid’s Prevention Potential for Neural Tube Defects

P13

Liang H-W1, Greenald D2, Birru R1, Zhao Y3, Koistinen H4, Mitchell R5, Xun X1, Wang J6, Snyder N7, Barrett E8, O’Connor T9, Miller R10, Simhan H11, Adibi JJ1. 1Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States, 2Centre for Reproductive Health, University of Edinburgh, South Bridge, United Kingdom, 3St. Jude Children's Research Hospital, Pittsburgh, PA, United States, 4HUSLAB, Helsinki University Hospital, Helsinki, Finland, 5Developmental Endocrinology, The University of Edinburgh, South Bridge, United Kingdom, 6Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States, 7Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States, 8Department of Biostatistics and Epidemiology, Rutgers-School of Public Health, Piscataway, NJ, United States, 9Psychiatry, University of Rochester, Rochester, NY, United States, 10School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, United States, 11Magee-Womens Research Institute, Pittsburgh, PA, United States. Evaluation of the Fetal Sex-Specific Effects of Mono-N-Butyl and Monobenzyl Phthalate on Placental Gene Expression in the First Trimester

P14

Ortiz-Newmark AM1, Rueda-Esteban RJ1, Sarmiento LA1,2. 1Universidad de los Andes School of Medicine, Bogota, Colombia, 2Gynecology Department Fundacion Santa Fe de Bogota, Bogota, Colombia. Sirenomelia, Cervical Myelomeningocele, and Meromelia: An Unusual AssociationCase Report and Literature Review

 

P15

Lu L, Yuan F, Liu J, Chen S-Y. Department of Pharmacology and Toxicology, Alcohol Research Center, University of Louisville Health Science Center, Louisville, KY, United States. Exposure of Human Forebrain Organoids to Ethanol Disrupted the Formation of Radial Glial Processes and Impaired the Generation, Migration, and Transformation of Outer Radial Glia Cells

P16

Wiegand JL, Cheng V, Reddam A, Avila-Barnard S, Volz D. University of California, Riverside, Riverside, CA, United States. Triphenyl Phosphate-Induced Pericardial Edema Is Associated with Elevated Epidermal Ionocytes within Zebrafish Embryos

P17

Dickson S, Waddell M, Zablocki V, Bailey B, Dodge P, Kopkau H, Nadolski K. Central Michigan University College of Medicine, Mount Pleasant, MI, United States. In Utero Effects of Opioids on Fetal Growth

Kumar SN1, Bastia B1, Deval R2, Bhardwaj SK3, Kumar N1, Borgohain D4, Akhtar N1, Raisuddin S5, Kumar Jain A1. 1Environmental Toxicology Lab, ICMR-NIP, New Delhi, India, 2Department of Biotechnology, IIET, Inverstis University, Bareilly, UP, Bareilly, India, 3Shimadzu Analytical India Pvt Ltd, DELHI, India, 4Assam Medical College, Dibrugarh, Assam, Dibrugarh, India, 5Department of Medical Elementology and Toxicology, Jamia Hamdard, DELHI, India. Organochlorine Pesticides Induce Oxidative Stress and DNA Damage in Tea Plantation Workers and Their Correlation with Fetal Growth Restrictions

P19

Ruden X1, Abdulhasan M2, Puscheck EE1, Ruden D1, Rappolee DA1. 1Wayne State University, Detroit, MI, United States, 2Reproductive Stress; Measurement, Mechanisms and Management S Corp., Grosse Pointe Farms, MI, United States. The Earliest Embryonic Stem Cell Lineage of the Blastocyst Has Two Fates and Some Toxicants Drive Fate One and Suppress Fate Two, While Others Drive Towards Fate Two

P20

Olufosoye O, Subramaniam S, Bailey B. Central Michigan University, College of Medicine, Mount Pleasant, MI, United States. Impact of In Utero Opioid Exposure on Developmental Delays and Growth at 12 Months of Age

P21

Memon S1, Singha S2, Memon F3, Isaac AD1. 1Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan, 2Isra University, Hyderabad, Pakistan, 3Altamash, Hospital, Karachi, Pakistan. Autism-Like Behavior and Astrocytic Changes Associated with Autism as Consequence of Pre and Postnatal Exposure to Bisphenol A in Wistar Albino Rat Offspring

P22

Kaldhone PR1, Bryant M2, Sepehr E3, He X2, Felton R2, LeeG4, Mellon RD4, Fisher JE4, Hanig J4, Beger RD2, Inselman AL2. 1FDA/ NCTR, Jefferson, AR, United States, 2FDA/NCTR, Jefferson, AR, United States, 3FDA/NCTR/CBER, Jefferson/Laurel, AR, United States, 4FDA/CDER, Silver Spring, MD, United States. Developmental Toxicity from Gestational Opioid Exposure in a CF-1 Mouse Model

P23

Green R1, Goodman CV1, Flora D1, Lanphear B2, Cill C1. 1York University, Toronto, ON, Canada, 2Simon Fraser University, Vancouver, BC, Canada. Comparison of the Associations between Prenatal Fluoride, Lead and Perfluoroalkyl Substances, and Boys IQ Scores in the MIREC Cohort

P24

Jamalpoor A, Hartvelt S, Flatt L, Zwetsloot T, Feliksik M, Osterlund T, Hendriks G. Toxys B.V., Oegstgeest, The Netherlands. ReproTracker: A Human Stem Cell-Based Biomarker Assay for In Vitro Assessment of Developmental Toxicity

P25

Kagan MS1, Zurakowski D1,2, Mongerson C1, Jennings RW2,3,4, Bajic D1,2. 1Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Department of Surgery, Boston Children’s Hospital, Boston, MA, United States, 4Esophageal and Airway Treatment Center, Boston Children’s Hospital, Boston, MA, United States. Mammillary Body Quantification in a Pilot Cohort of Critically Ill Infants

P26

Hall M1, Green R1, Goodman CV1, Lanphear B2, Till C1. 1Department of Psychology, Faculty of Health, York University, Toronto, ON, Canada, 2Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada. Maternal Hypothyroidism in Pregnancy is Associated with Lower IQ in Boys, but not Girls

P27

Gallego MP, Irijalba I, Quevedo C, Muriana A, Weiner A. BBD BioPhenix SL-Biobide, Donostia-San Sebastián, Spain. Validation of Zebrafish Embryotoxicity Test (ZET) as a Qualified Alternative Assay for its Regulatory Use

P28

Palmer JA, Donley EL, Burrier RE. Stemina Biomarker Discovery, Inc., Madison, WI, United States. devTOX quickPredict Accurately Predicts the Developmental Toxicity Potential of the ICH S5(R3) Guideline Reference Compounds

P29

Curran CP, Clough K, Foster E, Kyntchev A, Berling K, Perry C, Towell A, Feltner M, Honaker A, Creech H. Northern Kentucky University, Highland Heights, KY, United States. Biochemical and Microbiome Changes in Cyp1a1 Knockout and Wild Type Mice Following Developmental Exposure to benzo[a]pyrene

P30

Kula J, Davis D, Hrubec TC. Virginia College of Osteopathic Medicine, Blacksburg, VA, United States. Do Cytokine Profiles in Maternal Mouse Macrophages and Placental Tissue Influence the Formation of Neural Tube Defects in QAC Exposed Mice

P31

Sok P1, Sabo A2, Almli LM3, Jenkins MM3, Nembhard WN4, Agopian AJ5, Bamshad MJ6,7, Blue EE7,8, Brody LC9, Brown AL1, Browne ML10,11, Canfield MA12, Carmichael SL13, Chong JX6,7, Feldkamp ML14, Finnell RH15, Gibbs R2, Kay DM16, Lei Y15, Moore CA3, Mullikin JC9, Muzny D2, Olshan AF17, Pangilinan F9, Reefhuis J3, Romitti PA18, Schraw JM1, Shaw GM13, Werler MM19, Harpavat S20, Lupo PJ1. 1Pediatrics, Baylor College of Medicine, Houston, TX, United States, 2Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, United States, 3Centers for Disease Control and Prevention, Atlanta, GA, United States, 4Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, United States, 5Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas School of Public Health, Houston, TX, United States, 6Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, WA, United States, 7Brotman Baty Institute for Precision Medicine, Seattle, WA, United States, 8Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, United States, 9Genetics and Environment Interaction Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States, 10Birth Defects Registry, New York State Department of Health, Albany, NY, United States, 11Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, Rensselaer, NY, United States, 12Texas Department of State Health Services, Austin, TX, United States, 13Stanford University School of Medicine, Stanford, CA, United States, 14University of Utah School of Medicine, Salt Lake City, UT, United States, 15Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, United States, 16Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY, United States, 17University of North Carolina, Chapel Hill, NC, United States, 18University of Iowa, Iowa City, IA, United States, 19Boston University, Boston, MA, United States, 20Gastroenterology, Hepatology and Nutrition, Texas Children’s Hospital, Houston, TX, United States. Exome-Wide Assessment of Isolated Biliary Atresia: Using Child-Parent Trios and a Case-Control Design to Identify Novel Rare Variants

P32

Yost EE1, Chiang C1, Keating AF2, Christensen K3, Lehmann G1. 1US EPA, Research Triangle Park, NC, United States, 2Iowa State University, Ames, IA, United States, 3US EPA, Washington, DC, United States. Considerations for the Critical Appraisal of Animal Toxicology Studies on the Developmental Toxicity of PCBs

8:00 PM–10:00 PM


7:00 AM–6:00 PM


7:00 AM–8:00 AM


7:00 AM–8:00 AM


8:00 AM–9:00 AM


9:05 AM–12:00 Noon


9:05 AM–9:15 AM


9:15 AM–9:45 AM
S5


9:45 AM–10:15 AM
S6


10:15 AM–10:30 AM


10:30 AM–10:55 AM
S7


10:55 AM–11:30 AM
S8


11:30 AM–11:55 AM
S9


11:55 AM–12:00 Noon


9:05 AM–12:00 Noon





9:05 AM–9:15 AM


9:15 AM–9:30 AM
12


9:30 AM–9:45 AM
13


9:45 AM–10:00 AM
14


10:00 AM–10:15 AM
15


10:15 AM–10:30 AM


10:30 AM–10:45 AM
16


10:45 AM–11:00 AM
17


11:00 AM–11:15 AM
18


11:15 AM–11:30 AM
19


11:30 AM–11:45 AM
20


11:45 AM–12:00 Noon
21

12:00 Noon–2:00 PM


12:05 PM–1:45 PM
12:05 PM–12:10 PM


12:10 PM–12:40 PM


12:40 PM–1:45 PM


1:00 PM–2:00 PM


2:00 PM–2:30 PM


2:35 PM–5:55 PM


2:35 PM–3:00 PM
S10


3:00 PM–3:25 PM
S11


3:25 PM–4:00 PM
S12


4:00 PM–4:15 PM


4:15 PM–4:40 PM
S13


4:40 PM–5:05 PM
S14


5:05 PM–5:55 PM


2:35 PM–5:55 PM


2:35 PM–2:40 PM


2:40 PM–3:20 PM
S15


3:20 PM–4:00 PM
S16


4:00 PM–4:15 PM


4:15 PM–4:55 PM
S17


4:55 PM–5:35 PM
S18


5:35 PM–5:55 PM


6:00 PM–7:30 PM


P33

Peymani P1, Winquist B2,3, Shouman W1, Lavu A1, Delaney J1, Kowalec K1, Ng M4, Eltonsy S1,5. 1College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada, 2College of Medicine, University of Saskatchewan, Saskatoon, SA, Canada, 3Saskatchewan Health Quality Council, Saskatoon, SK, Canada, 4Section of Neurology, University of Manitoba, Winnipeg, MB, Canada, 5The Children’s Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. Trend Analysis of the Antiepileptic Drugs Utilization in Pregnant Women with Epilepsy in Canada

P34

Shan X1, Aguilar S2, Canon S1. 1Arkansas Children's Research Institute, Little Rock, AR, United States, 2University of Arkansas for Medical Sciences, Little Rock, AR, United States. Prevalence of Hypospadias by Degree of Severity and Associated Risk Factors

P35

Goli K1, Mimi Le2, Langlois PH3, Canfield MA2, Lupo PJ1, Schraw JM1. 1Baylor College of Medicine, Houston, TX, United States, 2Texas Department of State Health Services, Birth Defects Epidemiology and Surveillance Branch, Austin, TX, United States, 3University of Texas UTHealth School of Public Health, Austin, TX, United States. Maternal Hypertension and Structural Birth Defects: A Phenome-Wide Association Study

P36

Musfee FI1, Politis M1,2, Cen R1, Magann EF3,4, Nembhard WN3,5. 1Arkansas Center for Birth Defects Research and Prevention, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, United States, 2Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Arkansas Center for Birth Defects Research and Prevention, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, United States, 4Department of Maternal Fetal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States, 5Department of Epidemiology, Fay W Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, United States. Neighborhood Deprivation during Pregnancy and Risk of Stillbirths

P37

Bedard T1, Thomas MA2, Lowry RB2, Grevers X1, Crawford S3. 1The Alberta Congenital Anomalies Surveillance System, Clinical Genetics, Alberta Children's Hospital, Calgary, AB, Canada, 2Department of Medical Genetics, University of Calgary, Alberta Children's Hospital, Calgary, AB, Canada, 3Alberta Perinatal Health Program, Alberta Health Services, Calgary, AB, Canada. The Oculo-Auriculo-Vertebral Spectrum and Associated Congenital Anomalies in 63 Cases from the Alberta Congenital Anomalies Surveillance System, 1997–2019

P38

Wartko PD1, Singh U1, Howe A2, Shortreed SM1, D'Souza S3, Fuller S1, Mangione-Smith RM1, Dublin S1. 1Kaiser Permanente Washington Health Research Institute, Seattle, WA, United States, 2School of Medicine, University of Auckland, Auckland, New Zealand, 3School of Social Sciences, University of Auckland, Auckland, New Zealand. Trends in Antiemetic Medication Use in Pregnancy in an Integrated Health System in the US, 2010–2021

P39

Shumate C1, Navarro L1, Howell R1, Agopian AJ2, Canfield MA1. 1Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health and Human Services, Austin, TX, United States, 2Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas School of Public Health, Houston, TX, United States. Predicting Four-Year Mortality Among Infants with Birth Defects Using Two Comorbidity Indices: The Pediatric Medical Complexity Algorithm and the Charlson Comorbidity Index, Texas, 2010–2014

P40

Betancourt D1, Canfield MA1, Kubenka C1, Ethen M1, Shumate C1, Palacios J2. 1Texas Department of State Health Services, Birth Defects Epidemiology and Surveillance Branch, Austin, TX, United States, 2Harris Health System, Houston, TX, United States. Collaboration Between the Texas Birth Defects Registry and Social Workers to Connect Children with Birth Defects to Health and Social Service Programs

P41

Nava de Escalante Y1, Abayomi A1, Langlois S2,3, Xibiao Ye1,4, Erickson A1, Ngo H1, Armour R5, Arbour L3,6, Bedard T7, Der K2, Van Allen M3, Skarsgard E8,9, Lavoie M10, Henry B11. 1Office of Provincial Health Officer, Victoria, BC, Canada, 2Perinatal Services British Columbia, Vancouver, BC, Canada, 3Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada, 4Health Information Science, University of Victoria, Victoria, BC, Canada, 5Vital Statistics Agency (retired), Victoria, BC, Canada, 6Division of Medical Science University of Victoria, Victoria, BC, Canada, 7The Alberta Congenital Anomalies Surveillance System, Clinical Genetics, Calgary, BC, Canada, 8Division of Pediatric Surgery, University of British Columbia, Vancouver, BC, Canada, 9BC Children's Hospital, Vancouver, BC, Canada, 10Deputy Provincial Health Officer, Office of the Provincial Health Officer, Victoria, BC, Canada, 11Provincial Health Officer, Office of the Provincial Health Officer, Victoria, BC, Canada. The British Columbia Congenital Anomalies Surveillance System (BCCASS) Validation Study

P42

Fernandez ACG1,2, Padula A1, Basilio E1, Roger J1, Gaw S1, Robinson JF1. 1University of California, San Francisco, San Francisco, CA, United States, 2University of California, Berkeley, Berkeley, CA, United States. Retrospective Analysis of Wildfire Smoke Exposure during Pregnancy and Birth Weight Outcomes

P43

Abstract Withdrawn

P44

Hugonin-Rao B1,2. 1Department of Maternal-Fetal Health Azienda USL Toscana Centro, Florence, Italy, 2Future in Pediatrics, Florence, Naples, Salerno, Italy. Surveillance of Neural Birth Defects, from Preconceptional to Perinatal Health: FUTURA Project for a New Challenges for the Future

P45

Mohan H1, Nguyen J1, Yee A1, Yukino Laurette E1, Sanghvi T1, Tejada O1, Mackenzie B1, Guzman-Lenis M1, Greene N2, Copp A2, Serghides L1,3. 1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 2Developmental Biology and Cancer Department, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom,3Department of Immunology and Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada. Reproductive Feto-toxicity Studies to Evaluate Dolutegravir in Combination with Emtricitabine and Tenofovir in Pregnant Mice on a Folate Deficient Diet

P46

Baier B, Di Giacomo M, Hugger M. BI Pharma GmbH & Co KG, Biberach, Germany. Correlation of Body Weight Changes and Estrous Cycle in Laboratory Rats

P47

Catlin NR1, Bowman CJ1, Campion SN1, Nowland WS1, Sathish JG2, Stethem CM1, Updyke LW3, Cappon GD1. 1Pfizer Worldwide Research, Development, & Medical, Groton, CT, United States, 2Pfizer Worldwide Research, Development, & Medical, Pearl River, MS, United States, 3Pfizer Worldwide Research, Development and Medical, Cambridge, MA, United States. Reproductive and Developmental Safety of Nirmatrelvir (PF-07321332), an Oral SARS-CoV-2 Mpro Inhibitor in Animal Models

P48

Shafique S, Winn L. Queen's University, Kingston, ON, Canada. Histone Modifications within Murine Decidua Might Play a Role in Valproic Acid-Induced Teratogenesis

P49

Swenson KS, Bates E. University of Colorado, Anschutz Medical Campus, Aurora, CO, United States. The Effect of Fetal Cannabidiol (CBD) Exposure on Brain Development and Postnatal Behavior

P50

Tayem Y1, Veeramuthu S1, Rashid A2, Sequeira R1, Fadel R2. 1Department of Pharmacology and Therapeutics, Arabian Gulf University, Bahrain, 2Department of Anatomy, Arabian Gulf University, Bahrain. Effects of Prenatal Administration of Melamine on Pregnancy Outcome in Rats

P51

Blazejewski SM, Chapman S, Rendemonti J, Stanislaus DJ. GSK, Collegeville, PA, United States. Evaluation of Rabbit Whole Embryo Culture Model as Nonrodent Alternative for Early Screening

P52

Rychlik KA, Illingworth E, Sanchez IF, Attreed SE, Sanchez S, Sillé FC. Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States. Arsenic Exposure During Equivalent Second Trimester in C57BL/6 Mouse Model Leaves Long-Lasting Immune Alterations

P53

Campion S1, Catlin NR1, Bowman CJ1, Nowland WS1, Stethem C1, Lewis E2, Cappon G1. 1Pfizer Worldwide Research, Development, & Medical, Groton, CT, United States, 2Safety Assessment, Charles River Laboratories, Horsham, PA, United States. The Postnatal Resolution of Fetal Skeletal Malformations Inducted by Pharmacological DGAT2 Inhibition during Gestation

P54

Sparks NR, Williams D, zur Nieden NI. University of California, Riverside, CA, Riverside, CA, United States. Mechanisms of Tobacco-Induced Human ESC Skeletal Developmental Toxicity

P55

Avila-Barnard SG, Dasgupta S, Cheng V, Reddam A, Wiegand JL, Volz D. University of California, Riverside, Riverside, CA, United States. Tris(1,3-dichloro-2-propyl) Phosphate Disrupts the Normal Trajectory of Cytosine Methylation within Developing Zebrafish Embryos

P56

Yuan F, Lu L, Liu J, Chen S-Y. Department of Pharmacology and Toxicology, Alcohol Research Center, University of Louisville Health Science Center, Louisville, KY, United States. Reduction in the Activity of the Putative Enhancers of TFAP2A Contributes to Ethanol-Induced Impairment of the Migration of Human Neural Crest Cells

P57

Abstract Withdrawn

P58

Afsharian K1, Trinh V2, Wells PG1,3. 1Dept. of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada, 2Dept. of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada, 3Dept. of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. Oxidative DNA Damage in Fetal Brains of Brca1 Knockout Mice Following In Utero Ethanol Exposure

P59

Abstract Withdrawn

P60

Cheng AP1, Wells PG1,2. 1Dept. of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada, 2Dept. of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. Alterations in Gene Expression Potentially Involved in Developmental Disorders Caused by Oxidative DNA Damage in Oxoguanine Glycosylase 1 (Ogg1) Knockout Mice

P61

Chen H, Kapidzic M, Levan J, Gantar D, Okorie C, Basrai S, Aksel S, Abrahamsson D, Jigmeddagva U, Buarpung S, San A, Gaw S, Woodruff TJ, Fisher SJ, Robinson JF. University of California, San Francisco, San Francisco, CA, United States. Perfluorooctanoic Acid Induces Transcriptomic Alterations in Primary Human Villous Cytotrophoblasts

P62

Abstract Withdrawn

P63

Chen H, Kapidzic M, San A, Zeighami N, Hall S, Fisher S, Robinson JF. University of California, San Francisco, San Francisco, CA, United States. Perfluorooctanoic Acid Exposure Alters the Proteome of Primary Human Placental Villous Cytotrophoblasts



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