Program

Meeting Agenda

Society for Birth Defects Research and Prevention 2020 Annual Meeting—Honoring Teratology’s Roots, Growing a Healthier Future

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Only sessions designated with CME are eligible for Continuing Medical Education credit.

Unless otherwise noted, all sessions will be recorded and available on demand to meeting registrants for one year following the meeting.

Please note that all times listed are in EDT – Eastern Daylight Time (US).

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Thursday, June 11, 2020
12:30 PM–2:00 PM
COVID-19 and Pregnancy: What Do We Know and How Will We Learn More
Cohosted by the Organization of Teratology Information Specialists
Full Schedule


12:30 PM–12:35 PM
Introduction
Elise M. Lewis, Charles River


12:35 PM–1:05 PM
COVID-19 and Pregnancy: What Do We Know
Sonja A. Rasmussen, University of Florida


1:05 PM–1:35 PM
COVID-19 and Pregnancy: How Will We Learn More
Christina D. Chambers, University of California–San Diego


1:35 PM–2:00 PM
Discussion


Thursday, June 25, 2020
11:00 AM–11:05 AM
President's Welcome
BDRP President, Christine Perdan Curran, Northern Kentucky University


11:05 AM-11:45 AM
Josef Warkany Lecture
POPs: A Plethora of Developmental Effects (L1)
Chairperson: Christine Perdan Curran, Northern Kentucky University
Lecturer: Linda S. Birnbaum, Scientist Emeritus and Former Director, National Institute of Environmental Health Sciences and National Toxicology Program


11:45 AM–12:30 PM
CME
Robert L. Brent Lecture—Teratogen Update
From Dysmorphology to Next-Generation Phenotyping
Chairperson: Christine Perdan Curran, Northern Kentucky University
Lecturer: Karen W. Gripp, A.I. duPont Hospital for Children/Nemours


12:30 PM–12:45 PM
Break


12:45 PM–3:15 PM
Graduate Student and Postdoctoral Fellow Platform Session 1
Organized by the Student Affairs Committee
Chairperson: Ida M. Washington, West Virginia University

Full Schedule


Presenting author is underlined.


12:45 PM–12:51 PM
Introduction


12:51 PM–1:09 PM
1
Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Its Replacement GenX Induces Adverse Pregnancy Outcomes and Disrupts the Placenta
Blake BE1, Cope H1, Hall S2, Keys R1, Mahler B1, McCord J3, Scott B1, Stapleton H2, Strynar M3, Elmore S1, Fenton S1. 1NTPL/NIEHS, Research Triangle Park, NC, United States, 2Duke University, Durham, NC, United States, 3US EPA, Research Triangle Park, NC, United States


1:09 PM–1:27 PM
2
A Secondary Mechanism by Which Ethanol Enhances Macromolecular Damage and Behavioural Deficits in Brca1 Knockout Mice
Drake DM 1, Wells PG1,2. 1Department. of Pharmaceutical Sciences and the Centre for Pharmaceutical Oncology (CPO), University of Toronto, Toronto, ON, Canada, 2Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada


1:27 PM–1:45 PM
3
Ozone Exposure during Early Pregnancy Alters Energy Balance and Adipose Morphology in Female Long-Evans Rat Offspring by Six Months of Age
Nguyen HH1, Miller CN1, Stewart EJ1, Philips PM2, O'Shaughnessy KS2, Dye JA2. 1Oak Ridge Institute for Science and Education, Research Triangle Park, NC, United States, 2Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, US EPA, Research Triangle Park, NC, United States


1:45 PM–2:03 PM
4
Zika-Associated Birth Defects Among Infants with Possible Congenital Zika Virus Infection, Florida Zika Pregnancy and Infant Registry, January 2016–March 2018
Elmore AL1, Dixon A2, Prieto J3, McDermott C4, Morrison A4, Lowry J1, Lake-Burger H1, Stanek D4. 1Florida Department of Health, Florida Birth Defects Registry, Tallahassee, FL, United States, 2University of South Florida, Birth Defects Surveillance Program, Tampa, FL, United States, 3Fulton County Board of Health, Atlanta, GA, United States, 4Florida Department of Health, Bureau of Epidemiology, Tallahassee, FL, United States


2:03 PM–2:21 PM
5
A Phenome-Wide Association Study of the Associations between Maternal Diabetes and Structural Birth Defects in Offspring in 6.5 Million Live Births
Schraw JM1, Langlois PH2, Lupo PJ1. 1Baylor College of Medicine, Houston, TX, United States, 2Texas Department of State Health Services, Austin, TX, United States


2:21 PM–2:39 PM
6
Reproductive Toxicity Studies to Evaluate Potential Neural Tube and Other Abnormalities Associated with Dolutegravir Exposure in Pregnancy
Mohan H1, Guzman-Lenis M1, Yukino Laurette E1, Sanghvi T1, Tejada O1, Greene N2, Copp A2, Serghides L1. 1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 2Developmental Biology and Cancer Department, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom


2:39 PM–2:57 PM
7
Utilizing Toxicogeomics to Enhance Adverse Outcome Pathways and Testing Strategies
Chen H, Chidboy M, Robinson JF. Center for Reproductive Sciences and Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United States


2:57 PM–3:15 PM
8
Differences in Cell Proliferation and Inflammation Pathways Regulate Prenatal Alcohol Sensitivity in Mice
Boschen KE1, Mendoza-Romero HN1, Fish EW1, Peterson RL1, Eberhart JK2, Parnell SE1,3. 1Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, United States, 2Molecular Biosciences and Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, United States, 3Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, United States.


3:15 PM–4:30 PM
Presidents' Welcome Reception


Monday, June 29, 2020
11:00 AM–11:30 AM
F. Clarke Fraser New Investigator Award
Establishing a Research Program in Developmental Toxicology Utilizing In Vitro Models and Big Data Approaches
Chairperson: Suzanne E. Fenton, National Institute of Environmental Health Sciences
Lecturer: Joshua F. Robinson, University of California, San Francisco


11:30 AM–12:15 PM
James G. Wilson Publication Award
The effects of alcohol and cannabinoid exposure during the brain growth spurt on behavioral development in rats
Chairperson: Brian Enright, AbbVie Inc.
Lecturer: Kristen R. Breit, San Diego State University


12:15 PM–12:30 PM
Break


12:30 PM–2:30 PM
CME
Investigation of a Potential Outbreak of Birth Defects Symposium

Chairpersons: Sonja A. Rasmussen, University of Florida and
Cheryl S. Broussard, Centers for Disease Control and Prevention

Full Schedule


12:30 PM–12:55 PM
S1
Ten Steps to a Field Investigation of an Increased Rate of Birth Defects
Sonja A. Rasmussen, University of Florida


12:55 PM–1:20 PM
S2
Using Birth Defects Surveillance to Address a Possible Increased Rate of Birth Defects
Peter H. Langlois, Texas Department of State Health Services


1:20 PM–1:45 PM
S3
Developing Interventions in Response to an Increase
Cheryl S. Broussard, Centers for Disease Control and Prevention


1:45 PM–2:10 PM
S4
Communicating with the Public during a Public Health Emergency Response
Glen J. Nowak, University of Georgia


2:10 PM–2:30 PM
Discussion


12:30 PM–2:30 PM
CME
Gene Therapy: CRISPR/Cas9 Technology, Breakthroughs, and Ethical Challenges Symposium

Organized by the Public Affairs Committee
Chairpersons: Gloria D. Jahnke, National Institute of Environmental Health Sciences and
Evi Struble, US Food and Drug Administration

Full Schedule


12:30 PM–1:00 PM
S5
Introduction to CRISPR-Cas9 Gene Editing
Jennifer Mason, Clemson University


1:00 PM–1:30 PM
S6
The Use of CRISPR/Cas9 Technology to Study Congenital Malformations Caused by NAD Deficiency
Paul R. Mark, Spectrum Health Medical Group


1:30 PM–2:00 PM
S7
Gene Therapy Products Using CRISPR/CAS9: Applications and Regulatory Considerations
Shana D. Hardy, US Food and Drug Administration


2:00 PM–2:30 PM
S8
Ethical and Governance Considerations of Germline Gene Editing
Eric T. Juengst, University of North Carolina, Chapel Hill


2:30 PM–3:20 PM
Platform Session 2

Chairpersons: Linda G. Roberts, NapaTox Consulting LLC and Deirdre K. Tucker, Charles River Laboratories

Full Schedule


2:30 PM–2:40 PM
9
Pathogenic Copy Number Variants Associated with Neurodevelopmental Impairment Detected in Chromosomal Microarray Analysis in Neonates with Congenital Heart Defects
Findley TO1, Crain AK2, Mahajan S2, Solis Zavala A2, Davis J3, Rodriguez-Buritica DF3. 1Division of Neonatal-Perinatal Medicine, Department of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States, 2McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States, 3Division of Medical Genetics, Department of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States


2:40 PM–2:50 PM
10
Altered Mechanisms of Genital Development Identified Through Integration of DNA Methylation and Genomic Measures in Hypospadias
Richard MA1, Sok P1, Canon S2,3, Nembhard WN4, Brown AL1, Peckham-Gregory EC1, Ehli EA5, Kallsen NA5, Davies GE5, Patel A2,3, Zamilpa I2,3, Hobbs CA6, Scheurer ME1, Lupo PJ1. 1Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States, 2Arkansas Children's Hospital, Little Rock, AR, United States, 3Department of Urology, University of Arkansas for Medical Sciences, Little Rock, AR, United States, 4Department of Epidemiology and Arkansas Center for Birth Defects Research and Prevention, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, United States, 5Avera Institute for Human Genetics, Sioux Falls, SD, United States, 6Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States


2:50 PM–3:00 PM
12
Increased Body Mass Index and Birth Defects Prevalence Across South Carolina, 2016–2018
Humphries B, Leedom VO. South Carolina Department of Health and Environmental Control, Columbia, SC, United States


3:00 PM–3:10 PM
13
Patterns of Congenital Malformations Co-occurring with Nonsyndromic Gastroschisis and Omphalocele
Oluwafemi OO1, Benjamin RH1, Navarro Sanchez ML1, Scheuerle AE2, Schaaf CP3,4,5, Mitchell LE1, Langlois PH6, Canfield MA6, Swartz MD7, Scott DA5, Northrup H8, Ray JW9, McLean SD10, Ludorf KL1, Chen H1, 11, Lupo PJ12, Agopian A1. 1Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health, Houston, TX, United States, 2Department of Pediatrics, Division of Genetics and Metabolism, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Jan and Dan Duncan Neurological Research Institute, TX Children’s Hospital, Houston, TX, United States, 4Heidelberg University, Institute of Human Genetics, Heidelberg, Heidelberg, Germany, 5Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States, 6Birth Defects Epidemiology and Surveillance Branch, TX Department of State Health Services, Austin, TX, United States, 7Department of Biostatistics and Data Science, UTHealth School of Public Health, Houston, TX, United States, 8Department of Pediatrics, Division of Medical Genetics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States, 9Department of Pediatrics, Division of Medical Genetics and Metabolism, University of Texas Medical Branch, Galveston, TX, United States, 10Clinical Genetics Section, Children's Hospital of San Antonio, San Antonio, TX, United States, 11Center for Precision Health, UTHealth School of Public Health and UTHealth School of Biomedical Informatics, Houston, TX, United States, 12Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, United States


3:10 PM–3:20 PM
14
Maternal Periconceptional Alcohol Consumption and Gastroschisis in the National Birth Defects Prevention Study, 1997–2011
Fisher S1, Howley MM1, Romitti PA2, Desrosiers TA3, Anderson KN4, Jabs EW5, Browne ML1, 6. 1New York State Congenital Malformations Registry, New York State Department of Health, Albany, NY, United States, 2Department of Epidemiology, University of Iowa, Iowa City, IA, United States, 3Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States, 4National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States, 5Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 6Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, Rensselaer, NY, United States


3:30 PM–4:30 PM
Poster Session 1
Posters P1-P13 Attended for Questions & Answers
Poster Listings


P1

Foster ML, Donahue DA, Mahapatra D, Ovwigho P, Henry J. Integrated Laboratory Systems, Inc, Research Triangle Park, NC, United States. So You Want To Do Regulatory Developmental Neurotoxicology Studies: A Training and Validation Plan

P2

Bell KS1,2, Riutta C1,2, Jung G1, McCord J1, Ford JL1, Thomas SE1, 2, Wood CR1, Oshiro WO1, Gilbert ME1, O'Shaughnessy KS1. 1US EPA, Research Triangle Park, NC, United States, 2Oak Ridge Institute for Science and Education, Oak Ridge, TN, United States. Perfluorohexane Sulfonate (Pfhxs) Induces Maternal Hypothyroxinemia but Does Not Result in Developmental Neurotoxicity by a Thyroid-Mediated Mechanism

P3

Afsharian K1, Wells PG1,2. 1Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada, 2Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. Reactive Oxygen Species (ROS)-mediated Ethanol Embryopathies in Mouse Embryo Culture

P4

Cheng AP1, Bhatia S1, Wells PG1,2. 1Department of Pharmaceutical Sciences and Centre for Pharmaceutical Oncology, University of Toronto, Toronto, ON, Canada, 2Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. DNA Double-Strand Breaks in Fetal Brains from Oxoguanine Glycosylase 1 (OGG1) Knockout Mice Exposed In Utero to Physiological or Ethanol-enhanced Levels of Reactive Oxygen Species (ROS)

P5

Kancherla V1, Wagh K1, Pachon H2, Oakley Jr. GP1. 1Emory University Rollins School of Public Health, Atlanta, GA, United States, 2Food Fortification Initiative, Atlanta, GA, United States. A 2019 Global Update on Folic Acid-Preventable Spina Bifida and Anencephaly

P6

Manandhar M1, Beydoun H2, Kancherla V1. 1Emory University Rollins School of Public Health, Atlanta, GA, United States, 2Department of Research Programs, Fort Belvoir Community Hospital, Fort Belvoir, VA, United States. Body Mass Index and Folate Insufficiency Indicative of Neural Tube Defects Risk Among Nonpregnant Women of Childbearing Age in the United States, NHANES, 2007–2010

P7

Narotsky MG1, Lucas KE1,2. 1US Environmental Protection Agency, Research Triangle Park, NC, United States, 2Oak Ridge Institute for Science and Education, Oak Ridge, TN, United States. Dibromoacetic Acid is a More Potent Teratogen than Diiodoacetic Acid in a Developmental Toxicity Screen with F344 Rats

P8

Varshavsky JR1, Robinson JF1,2, Zhou Y2, Puckett KA2, Kwan E2, Buarpung S2, Aburajab R2, Gaw SL2,3, Sen S4, Crispo Smith S5, Frankenfield J5, Park J-S5, Fisher SJ2, Woodruff TJ1. 1Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United States, 2Center for Reproductive Sciences and Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United States, 3Division of Maternal-Fetal Medicine and Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United States, 4University of Tennessee Health Science Center, Department of Preventive Medicine, Memphis, TN, United States, 5California Environmental Protection Agency, Department of Toxic Substances Control, Environmental Chemistry Laboratory, Berkeley, CA, United States. Environmental Chemical Exposures During Mid-gestation and Biomarkers of Placental Development

P9

Inselman AL1, Kaldhone PR1, Merry G1, Fisher JE2, Mellon RD2, Hanig J2, Lee G2. 1US FDA, NCTR, Jefferson, AR, United States, 2US FDA, CDER, Silver Spring, MD, United States.Preliminary Investigation of Opioid Induced Neural Tube Defects in a Mouse Model

P10

Roth AE, Deissinger M, Rochelle A. New Mexico Department of Health, Santa Fe, NM, United States. Evaluation of New Mexico Neonatal Abstinence Syndrome Education Materials: How to Avoid Offending Your Audience

P11

Campbell MA1, Iyer P2, Kaufman F2, Kim A1, Moran F2, Niknam Y1, Wu L2, Sandy MS1, Zeise L1. 1OEHHA, Cal-EPA, Oakland, CA, United States, 2OEHHA, Cal-EPA, Sacramento, CA, United States. Evidence Considered in Determination of Cannabis Smoke and Δ9-Tetrahydrocannabinol (THC) as Causing Reproductive Toxicity (Developmental Endpoint)

P12

Liu S1, Junichi T2. 1Kao corporation, Haga, Tochigi, Japan, 2KAO, Tochig, Tochi, Japan. Chemical-Induced Craniofacial Anomalies in Zebrafish Embryos

P13

Buttling LG1, McKnight M2, Gohlke J1, Kolivras K2, Marston M2, Ranganathan S3. 1Department of Population Health Sciences, Virginia Tech, Blacksburg, VA, United States, 2Department of Geography, Virginia Tech, Blacksburg, VA, United States, 3Department of Statistics, Blacksburg, VA, United States. Maternal Residential Proximity to Central Appalachian Surface Mining and Adverse Birth Outcomes

Tuesday, June 30, 2020
11:00 AM–11:45 AM
CME
Prenatal Genomic Medicine: Transforming Obstetric
Practice and Delivering New Biological Insights (L3)
Chairperson: Elise M. Lewis, Charles River
Speaker: Diana W. Bianchi, Eunice Kennedy Shriver National Institute of Child Health and Human Development


11:45 AM–12:15 PM
Agnish Fellowship Lecture
Educating Future Birth Defects Researchers: Opportunities in the Era of Personalized Medicine, Systems Biology, and CRISPR Technologies
Chairperson: Caren Villano, Bristol-Myers Squibb
Speaker: Elaine M. Faustman, University of Washington


12:15 PM–12:30 PM
Break


12:30 PM–2:30 PM
CME
Opioid Use in Pregnancy: Translational Perspectives Symposium
(Joint with DNTS)
Chairpersons: Christina D. Chambers, University of California–San Diego;
Rina D. Eiden, Pennsylvania State University; and
Jennifer Willford, Slippery Rock University
Full Schedule


12:30 PM–1:00 PM
S9
Outcomes among Children of Opiate Using Mothers
Elisabeth Conradt, University of Utah


1:00 PM–1:30 PM
S10
A Translational Model of Gestational Buprenorphine Exposure: Effects on the Dam and the Offspring
Susanne Brummelte, Wayne State University


1:30 PM–2:00 PM
S11
Prenatal Exposure to Opioids and Other Substances: What Do We Know about Later Development Outcomes?
Hendrée Jones, UNC Department of Obstetrics & Gynecology


2:00 PM–2:30 PM
S12
Modifying an Evidence-Based Home Visiting Intervention for Mothers with Opioid Dependence
Mary Dozier, University of Delaware


12:30 PM–2:30 PM
CME
Assessing and Modeling Perinatal and Postnatal Exposures to Environmental Chemicals in Support of Human Health Risk Assessment Symposium

Chairpersons: Laura Carlson, US Environmental Protection Agency and Geniece Lehmann, US Environmental Protection Agency

Full Schedule


12:30 PM–12:50 PM
S13
Environmental Chemicals in Breast Milk and Formula: Exposure and Risk Assessment Implications
Judy S. LaKind, LaKind Associates


12:50 PM–1:10 PM
S14
Level of Detail for Pharmacokinetic Modeling During Development: Time or Tissues, But Not Both
Paul M. Schlosser, US Environmental Protection Agency


1:10 PM–1:30 PM
S15
Pharmacokinetic Modeling As a Tool to Bridge In Vitro, In Vivo, and Epidemiological Data in Risk Assessment of Developmental Exposures
Marc-Andre Verner, University of Montréal


1:30 PM–2:00 PM
S16
Children’s Nondietary Exposures to Environmental Chemicals
Paloma I. Beamer, University of Arizona


2:00 PM–2:20 PM
S17
A Review of Factors Influencing Children’s Exposure Assessment
Geniece Lehmann, US Environmental Protection Agency


2:20 PM–2:30 PM
Discussion


2:30 PM–3:20 PM
Platform Session 3

Chairpersons: Kimberly C. Brannen, Merck and Mark Herberth, Charles River

Full Schedule


2:30 PM–2:40 PM
15
Risk Factors and Time Trends for Diagnosis of Nonsyndromic Craniosynostosis
Schraw JM1, Woodhouse J1, Langlois PH2, Canfield MA2, Scheuerle AE3, Agopian A4, Benjamin RH4, Lupo PJ1. 1Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States, 2Texas Department of State Health Services, Austin, TX, United States, 3University of Texas Southwestern Medical Center, Dallas, TX, United States, 4University of Texas School of Public Health, Houston, TX, United States


2:40 PM–2:50 PM
16
Use of Cluster Analysis to Better Define a Distinct Clinical Phenotype Associated with Possible Congenital Zika Virus Infection
Zambrano LD1, Delaney A1, Gilboa SM1, Tong V1, Cragan JD1, Valencia M2, Roth NM1, Moore J1, Staples JE3, Honein MA1, Moore CA1. 1National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Departamento de Salud de Puerto Rico, San Juan, PR, United States, 3National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States


2:50 PM–3:00 PM
17
Prenatal Acetaminophen Use and Adverse Pregnancy Outcomes in Women with Autoimmune Conditions
Killon J1, Chambers CD1,2, Bandoli G1,2. 1Department of Family Medicine and Public Health, University of California San Diego, San Diego, CA, United States, 2Department of Pediatrics, University of California San Diego, La Jolla, CA, United States


3:00 PM–3:10 PM
18
The Role of In Utero Exposure to Drugs Beyond Opioids in the Development and Severity of Neonatal Opioid Withdrawal Syndrome (NOWS)
Bailey BA1, Wood DL2, Shah DS2. 1Central Michigan University, Mt Pleasant, Michigan, United States, 2East Tennessee State University, Johnson City, TN, United States


3:10 PM–3:20 PM
19
Multi-Modal Assessment of Stress-Reactivity and Self-regulation in the Newborn Period in a Prospective Cohort Study of Moderate Alcohol Exposure
Bakhireva LN1, Ruyak S1, Roberts M1, Rodriguez DE1, Leeman L1, Stephen J2, Maxwell JR1. 1University of New Mexico Health Sciences Center, Albuquerque, NM, United States, 2The Mind Research Network, Albuquerque, NM, United States


3:30 PM–4:30 PM
Poster Session 2
Posters P14-P26 Attended for Questions & Answers
Poster Listings


P14

McTaggart S1, MacColl G1, Gronkowski K1, Wood R1,2, Bennie M1,3. 1NHS National Services Scotland, Information Services Division, Edinburgh, Lothian, United Kingdom, 2University of Edinburgh, Edinburgh, Lothian, United Kingdom, 3University of Strathclyde, Glasgow, Greater Glasgow & Clyde, United Kingdom. The Impact of Regulatory Guidance on Valproate Prescribing and Harm Reduction for Females of Childbearing Potential: A National, Population Based Study in Scotland

P15

Chang X1, Lumen A2, Palmer J3, Lee UJ2,4, Ceger P1, Donley B3, Bell S1, Allen D1, Casey W5, Kleinstreuer NC5. 1Integrated Laboratory Systems, Inc, Research Triangle Park, NC, United States, 2US FDA/NCTR, Jefferson, AR, United States, 3Stemina Biomarker Discovery, Cambridge, MA, United States, 4Albert Einstein College of Medicine, Bronx, NY, United States, 5NIEHS/NTP, Durham, NC, United States. In Vitro to In Vivo Extrapolation for Developmental Toxicity Potency of Valproate Analogues

P16

Wood R1,2, Hopkins L1, Goulding A1, Vieira R3. 1NHS National Services Scotland, Information Services Division, Edinburgh, Lothian, United Kingdom, 2University of Edinburgh, Edinburgh, Lothian, United Kingdom, 3University of Aberdeen, Aberdeen, Grampain, United Kingdom. Establishing a National Congenital Anomaly Register for Scotland: Production of Baseline Estimates of Anomaly Birth Prevalence by Linkage and Analysis of Existing National Records

P17

SERREAU PR1,2, BAJJOU N3, AMIROUCHE A4, RIGOURD V5, RAI B6, MARBOIS C4, OMBOLO C4. 1Orleans Metropole, Orléans, Centre Val de Loire, France, 2Psycomadd INSERM AP-HP 6 University Paris Saclay, Villejuif, Ile de France, France, 3Orleans Métropole, Orléans, Centre Val de Loire, France, 4Psycomadd INSERM AP-HP 6 Université Paris Saclay, Villejuif, Ile de France, France, 5Milk Bank University Necker Hospital, Paris, Ile de France, France, 6JBR University, Copenhaguen, Hovenstaden, Denmark. Creation of the "PARADICT-O" Center to Prevent Maternal Drug Toxicity after Occupational Exposure in Orleans Metropole

P18

Maity S1, Downing KF2, Gilboa SM2, Politis MD1, Bolin E3, Nembhard WN1. 1Department of Epidemiology and Arkansas Center for Birth Defects Research and Prevention, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, United States, 2National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States, 3Arkansas Center for Birth Defects Research and Prevention, Arkansas Children’s Hospital Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. Trends in Mortality Associated with Congenital Heart Defects in the United States, 2007–2017

P19

Horton J1, Hootnick DR2. 1Upstate Medical University, Syracuse, NY, United States, 2Upstate Medical University, Syracuse, NY, United States. Embryonic Arterial Dysgenesis in Congenital Anteromedial Bowing of the Tibia: A Hypothesis

P20

Nalbandyan M1, Howley MM1, Cunniff CM2, Leckman-Westin E3, Browne ML1. 1New York State Department of Health, Albany, NY, United States, 2New York-Presbyterian Hospital/Weill Cornell Medicine, New York, NY, United States, 3NYS Office of Mental Health, Albany, NY, United States. Descriptive and Risk Factor Analysis of Infantile Cataracts: National Birth Defects Prevention Study, 2000–2011

P21

Maxwell JR1, Roberts M1, Ma X1, Rodriguez DE1, Enriquez Marquez L1, Beauman SS1, Lacy CS1, Bakhireva LN1, Stephen J2. 1University of New Mexico, Albuquerque, NM, United States, 2The Mind Research Network, Albuquerque, NM, United States. Moderate Prenatal Alcohol Exposure and Infant Heart Rate Variability Measures Following Birth

P22

Behlen JC1, Carmen LH2, Li Y3, Stanley JA4, Zhang R3,5, Johnson NM1. 1Department of Environmental and Occupational Health, Texas A&M University, College Station, TX, United States, 2Department of Veterinary Pathobiology, Texas A&M University, College Station, TX, United States, 3Department of Chemistry, TX A&M University, College Station, TX, United States, 4Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, United States, 5Department of Atmospheric Sciences, Texas A&M University, College Station, TX, United States. Exposure to Ultrafine Particulate Matter During Gestation Potentially Disrupts Placental Function

P23

Patel JR1, Schraw JM2,3, Lupo PJ2,4, Mian A5,6, Nembhard WN1,6. 1Department of Epidemiology and Arkansas Center for Birth Defects Research and Prevention, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, United States, 2Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States, 3Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX, United States, 4Texas Children’s Cancer Center, Texas Children’s Hospital, Houston, TX, United States, 5Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States, 6Arkansas Children's Research Institute, Little Rock, AR, United States. Pediatric Cancer Risk based on Attained Age among Children with Birth Defects in Arkansas

P24

Roth NM1, Russell Woodworth K2, Godfred-Cato S2, Delaney A1, Olson SE3, Nahabedian JF1, Carr C2,4, Whitehill F2,4, Lee E5, Ellis EM6, Tonzel JL7, Higgins CA8, Chan RL9, Tong V2, Gilboa SM2, Cragan JD2, Honein MA2, Moore CA2. 1Eagle Global Scientific, LLC, Atlanta, GA, United States, 2Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GA, United States, 3G2S Corporation, San Antonio, TX, United States, 4Oakridge Institute for Science and Education, Oak Ridge, TN, United States, 5New York City Department of Health and Mental Hygiene, New York City, NY, United States, 6US Virgin Islands Department of Health, St. Croix, USVI, US Virgin Islands, 7Florida Department of Health, Tallahassee, FL, United States, 8Massachusetts Department of Public Health, Boston, MA, United States, 9North Carolina Department of Health and Human Services, Raleigh, NC, United States. Possible Inaccuracy in Reported Head Circumference at Birth in the US Zika Pregnancy and Infant Registry

P25

Pierro JD1, Baker NC2, Knudsen TB1. 1US Environmental Protection Agency, Office of Research and Development, Research Triangle Park, NC, United States, 2Leidos, Research Triangle Park, NC, United States. Review of Retinoid Signaling in Skeletal Development for Adverse Outcome Pathways and Predictive Toxicology Applications

P26

Kimura E, Mongan M, Xia Y. University of Cincinnati, Cincinnati, OH, United States. Genetic and Environmental Etiology for Developmental Abnormalities of the Female Reproductive Tract



Wednesday, July 1, 2020
11:00 AM–12:00 Noon
Innovator Award Finalists Platform Session 4
Chairperson: Suzanne E. Fenton, National Institute of Environmental Health Sciences

Full Schedule


11:00 AM–11:20 AM
21
Studying Gene-Environmental Interactions in Autism with iPSC-derived BrainSpheres: microRNA and Metabolic Biomarkers of the Synergy
Smirnova L1, Zhong X1, Modafferi S1, Fagiani F1, Kleensang A1, Murata Y1, Hartung T2. 1Johns Hopkins University, Baltimore, MD, United States, 2Johns Hopkins Universoty, Baltimore, MD, United States


11:20 AM–11:40 AM
22
ReproTracker: A Human Stem Cell-Based Biomarker Assay for In Vitro assessment of Developmental Toxicity
Dimopoulou M, Hartvelt S, Zwetsloot T, Racz P, Brandsma I, Hendriks G. Toxys B.V., Leiden, Leiden, The Netherlands


11:40 AM–12:00 Noon
23
A Tale of Two Livers: The Impact of Sex on Hepatic Gene Expression in the Adolescent Rat Exposed to Ozone During Implantation
Miller CN1, Stewart EJ2, Schladweiler MC3, Ren H3, Valdez MC1, Fisher A3, Kodavanti UP3, Dye JA3. 1Oak Ridge Institute for Science and Education, Research Triangle Park, NC, United States, 2Oak Ridge Institute for Science and Education, Research Triangle Park, NC, United States, 3Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Research Triangle Park, NC, United States


12:00 Noon–12:30 PM
Warkany Tea


12:30 PM–2:30 PM
CME
Wiley Symposium
Pregnancy, Environment, and Child Health: A Focus on Obesity and Metabolic Disorders

Chairpersons: Suzanne E. Fenton, National Institute of Environmental Health Sciences and
Jerrold J. Heindel, Commonweal

Full Schedule


12:30 PM–12:54 PM
S18
Endocrinological and Environmental Control of Obesity
Jerrold J. Heindel, Commonweal

12:54 PM–1:18 PM
S19
Environmental Influences on the Childhood Obesity Epidemic
Leonardo Trasande, NYU School of Medicine


1:18 PM–1:42 PM
S20
Effects of Developmental Exposure to Genx on Mouse Offspring: Pubertal and Metabolic Targets
Suzanne E. Fenton, National Institute of Environmental Health Sciences


1:42 PM–2:06 PM
S21
How Does Prenatal Obesogen Exposure Lead to a Transgenerational Predisposition to Obesity?
Bruce Blumberg, University of California, Irvine


2:06 PM–2:30 PM
S22
The Role of Maternal Obesity and Pregnancy Weight Gain Patterns in Pregnancy and Birth, and Longer-Term Health Outcomes
Elizabeth Widen, University of Texas at Austin


12:30 PM–2:30 PM
HESI Symposium
Assessing Pregnancy Risk of Immunomodulators

Chairpersons: Caren Villano, Bristol-Myers Squibb and
Dinesh J. Stanislaus, GlaxoSmithKline

Full Schedule


12:30 PM–12:55 PM
S23
Immune Mechanisms and Immunoregulation: Role in Fertility, Gestation, and Parturition
Joanne Kwak-Kim, Rosalind Franklin University of Medicine and Science


12:55 PM–1:20 PM
S24
Current Methods to Assess Pregnancy Risk for Immunomodulators
Caren Villano, Bristol-Myers Squibb


1:20 PM–1:45 PM
S25
Case Studies: Gestational Exposures to Immunomodulators in Nonclinical Species
Aimee Hillegas, GlaxoSmithKline


1:45 PM–2:10 PM
S26
Gaps in Evaluation of Immune Function during Pregnancy: Workshop Summary
Christopher J. Bowman, Pfizer Inc.


2:10 PM–2:30 PM
Panel Discussion


2:30 PM–3:30 PM
Platform Session 5
Chairpersons: Philip Lupo, Baylor College of Medicine and Kristina York, Charles River Laboratories

Full Schedule


2:30 PM–2:40 PM
24
Adverse Outcome Pathways for Developmental Toxicity Gleaned from the Embryological Literature: A Rich and Rutted Road
Rogers JM. US Environmental Protection Agency, Research Triangle Park, NC, United States


2:40 PM–2:50 PM
25
Automated Applications of Ontologies to Standardize Developmental Toxicology Study Extraction
Foster C1, Wignall J1, Kovach S1, Trgovcich J1, Varghese A1, Rochester J1, Stout M2, Kleinstreuer NC2. 1ICF International Inc, Durham, NC, United States, 2NIEHS/NTP, Durham, NC, United States


2:50 PM–3:00 PM
26
Mouse Model of Dolutegravir-Induced Neural Tube Defects
Bredehoeft MR, Feser-Stessman HA, Hulen J, Hallgren J, Gelineau-van Waes J. Creighton University, Omaha, NE, United States


3:00 PM–3:10 PM
27
Alterations in the Mouse Placenta After Preconception and Prenatal Arsenic Exposure
Rychlik KA, Kashiwagi C, Liao J, Sillé FC. Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States


3:10 PM–3:20 PM
28
Quantitative Proteomic Analyses of Perfluorooctanoic Acid with Primary Human Villous Trophoblasts
Chen H, Williams K, San A, Kapidzic M, Hall S, Fisher SJ, Robinson JF. University of California, San Francisco, San Francisco, CA, United States


3:20 PM–3:30 PM
29
Quantification of the Uncertainties in Extrapolating from In Vitro Androgen Receptor (AR) Antagonism to In Vivo Hershberger Assay Endpoints and Adverse Reproductive Development in Male Rats
Gray EE. US EPA, ORD, CPHEA, PHITD, RDTB, Durham, NC, United States


3:30 PM–4:30 PM
Poster Session 3
Posters P27-P40 Attended for Questions & Answers
Poster Listings


P27

Mylchreest E1, Smiley A1, Ballin J2, Savransky V3. 1Battelle, West Jefferson, OH, United States, 2Battelle, Aberdeen, MD, United States, 3Emergent BioSolutions, Gaithersburg, MD, United States. AV7909 Anthrax Vaccine: Reproductive and Developmental Toxicity and Acute Phase Response

P28

Yost EE1, Nachman R2, Arzuaga X2, Sasso A2, Gibbons C2. 1US Environmental Protection Agency, Research Triangle Park, NC, United States, 2US Environmental Protection Agency, Washington, DC, United States. Incorporating Evaluation of Reporting Quality, Risk of Bias, and Sensitivity into the Weight-of-Evidence for Male Reproductive Toxicity: Case Study for Hexavalent Chromium

P29

Solomon HM1, Romach BH2, Stanislaus DJ1. 1GlaxoSmithKline Pharmaceuticals, Collegeville, PA, United States, 2ViiV Healthcare, Research Triangle Park, NC, United States. Fostemsavir: Reproductive and Juvenile Toxicity Studies in Rats and Rabbits

P30

York KA, Chellman GJ, Calise D, Newcomb DL. Charles River Laboratories, Reno, NV, United States. Impact of Immunogenicity on Conduct and Interpretation of NHP EFD and ePPND Studies

P31

Iturria I, Jaka O, Marti C, Muriana A, Mazón MJ. Biobide, San Sebastian, Gipuzkoa, Spain. Development of a Zebrafish Larvae Screening Assay to Identify Compounds with Immunotoxicity and Anti-Inflammatory Activity

P32

Palmer J, Smith AM, Colwell MR, Donley B, Burrier RE. Stemina Biomarker Discovery, Inc., Madison, WI, United States. Defining the Reproducibility and Applicability Domain of devTOX quickPredict, a Human Pluripotent Stem Cell-Based Developmental Toxicity Assay

P33

LIU S1, TASAKI J2, NARUMI R2, IEKI T1, IKEDA N2, MORITA O1. 1Kao Corporation, Haga, Tochigi, Japan, 2Kao Corporation, Kawasaki, Kanagawa, Japan. Chemical-Induced Craniofacial Anomalies in Zebrafish Embryos

P34

Narumi R1, Tasaki J1, Liu S2, Ieki T2, Ikeda N1, Morita O2. 1Kao Corporation, Kawasaki, Kanagawa, Japan, 2Kao corporation, Haga, Tochigi, Japan. Chemical-induced Cleft Palate in Zebrafish Embryos

P35

Abstract Withdrawn

P36

Sipek Sr A1,2,3, Gregor V1,2, Horacek J1,3, Klaschka J4,5, Maly M4,6, Sipek Jr A1,7,8. 1Department of Medical Genetics, Thomayer Hospital, Prague, The Czech Republic, 2Department of Medical Genetics, Pronatal Sanatory, , Prague, The Czech Republic, 3GENNET,  Prague, The Czech Republic, 4Institute of Computer Science of the Czech Academy of Sciences,  Prague, The Czech Republic, 5Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University,  Prague, The Czech Republic, 6National Institute of Public Health, Prague, The Czech Republic, 7Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, The Czech Republic, 8Institute of Medical Genetics, 3rd Faculty of Medicine, Charles University,  Prague, The Czech Republic. Decreasing Incidence of the Anencephaly in the Czech Republic: Long-Term Population-Based Study

P37

Sipek Jr A1,2,3, Gregor V1,4, Klaschka J5,6, Maly M5,7, Sipek Sr A1,4,8. 1Department of Medical Genetics, Thomayer Hospital, Prague, The Czech Republic, 2Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University,  Prague, The Czech Republic, 3Institute of Medical Genetics, 3rd Faculty of Medicine, Charles University, Prague, The Czech Republic, 4Department of Medical Genetics, Pronatal Sanatory,  Prague, The Czech Republic, 5Institute of Computer Science of the Czech Academy of Sciences,  Prague, The Czech Republic, 6Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Prague, The Czech Republic, 7National Institute of Public Health,  Prague, The Czech Republic, 8GENNET,  Prague, The Czech Republic. Increased Incidence of Congenital Anomalies in Children Born After Assisted Reproduction in the Czech Republic: Population Based Study

P38

Love C1, Cope H1, Blake B1,3, Phan T1,4, Brooks A2, Li J2, Hobbie K5, Fenton S1. 1DNTP, NIEHS, Research Triangle Park, NC, United States, 2DIR, NIEHS, Research Triangle Park, NC, United States, 3Curriculum in Toxicology, UNC, Chapel Hill; 4Department of Biological Sciences, NCSU, Raleigh, NC, United States, 5ILS, Research Triangle Park, NC, United States. Comparative Evaluation of Murine Mammary Gland Developmental Abnormalities and Transcriptomic Profiles Following In Utero Exposure to PFOA and GenX

P39

Anetor JI1,2, MacDonald A1, Huang D1, Ikeh-Tarawali P3, Charles- Davis MA4, Arowojolu A5, Kinniburgh DW1. 1Alberta Centre For Toxicology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 2Laboratory for Toxicology & Micronutrient Metabolism, Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria, 3Department of Chemical Pathology, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria, 4Endocrinology Unit, Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria, 5Department of Obstetrics and Gynecology, College of Medicine, University of Ibadan, Oyo State, Nigeria. Biomonitoring and Surrogate Biomonitoring Studies: Results from Two Economically Diverse Countries and Significance for Birth Defects Risk and Prevention

P40

Anetor JI, MacDonald A, Huang-Yu D, Kinniburgh DW. Alberta Centre For Toxicology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. Differential Pooled Chemical Levels in Maternal and Cord Paired Serum Samples in the Alberta Biomonitoring Program: Implications for Risk of Birth Defects and Prevention

Thursday, July 2, 2020
11:00 AM–12:00 Noon
BDRP and European Teratology Society Exchange Lecture
Early Principles of Teratology: Does Karnofsky’s Law Still Apply
Chairpersons: Susan L. Makris, US Environmental Protection Agency and
Nicola Suzanne Powles-Glover, AstraZeneca

Dr. David Karnofsky: The First 50 Years
European Teratology Society
Derek R Newall, European Teratology Society Past-President

Dr. David Karnofsky: Can He Rest in Peace or Do We Have a Way to Go?
BDRP
Alan M. Hoberman, Charles River


12:15 PM–2:15 PM
CME
Single-Cell Revolution: Embryogenesis at High-Resolution Symposium

Organized by the BDRP Science Committee

Chairpersons: Thomas B. Knudsen, National Center for Computational Toxicology, US EPA and
Elaine M. Faustman, University of Washington

Full Schedule


12:15 PM–12:45 PM
S27
Teratogenesis at the Single-Cell Level: Opportunities and Challenges
Thomas B. Knudsen, National Center for Computational Toxicology, US EPA


12:45 PM–1:15 PM
S28
Development and Disease at Single Cell Resolution
Malte Spielmann, Max Planck Institute for Molecular Genetics


1:15 PM–1:45 PM
S29
What scRNAseq Is Now Telling Us about Embryology
Sean Megason, Harvard Medical School


1:45 PM–2:15 PM
S30
How Single-Cell Profiling Data Can Be Applied to Improve Children’s Health
Elaine M. Faustman, University of Washington


2:15 PM–2:30 PM
Panel Discussion


2:30 PM–3:20 PM
Platform Session 6

Chairpersons: Bruce K. Beyer, Sanofi U.S. Inc. and Alan M. Hoberman, Charles River

Full Schedule


2:30 PM–2:40 PM
30
Evaluation of Bisphenol Analogue Exposure on Mouse Adipose Gene Expression In Vivo and In Vitro Using 3T3-L1 Cells
Chappell VA, Tucker DK, Fenton S. NTPL/NIEHS, Research Triangle Park, NC, United States


2:40 PM–2:50 PM
31
Maternal Diabetes and Risk for Birth Defects, by Race and Ethnicity, National Birth Defects Prevention Study, 1997–2011
Tinker SC1, Gilboa SM1, Moore CA1, Waller DK2, Simeone RM1, Kim SY1, Jamieson DJ3, Botto LD4, Fisher S5, Reefhuis J1. 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2University of Texas Health Science Center at Houston, Houston, TX, United States, 3Emory University School of Medicine, Atlanta, GA, United States, 4University of Utah School of Medicine, Salt Lake City, UT, United States, 5New York State Department of Health, Albany, NY, United States


2:50 PM–3:00 PM
32
Modeling Shows High Potential for Preventing Major Neural Tube Defects with Folic Acid Fortification of Iodized Salt
Kancherla V1, Tsang B2, Dixon MA1, Wagh K1, Oakley G Jr1. 1Emory University Rollins School of Public Health, Atlanta, GA, United States, 2Food Fortification Initiative, Atlanta, GA, United States


3:00 PM–3:10 PM
33
Spina Bifida Lesion Level Changes Before and After Mandatory Folic Acid Fortification in the United States
Mai C1, Adisa O1,2, Evans J3, Arnold K1, Flood T4, Frohnert B5, Alverson C1, Denson L6, Nestoridi E7, Nance A8, Leedom V9, Shan X10, Ethen M11, Eckert V12, Kirby R13. 1National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GA, United States, 2P3S Corporation, Atlanta, GA, United States, 3University of Manitoba, Winnipeg, MB, Canada, 4Arizona Department of Health Services, Phoenix, AZ, United States, 5Minnesota Department of Health, St. Paul, MN, United States, 6Oklahoma State Department of Health, Oklahoma City, OK, United States, 7Massachusetts Department of Public Health, Boston, MA, United States, 8Utah Department of Health, Salt Lake City, UT, United States, 9South Carolina Dept. of Health & Environmental Control, Columbia, SC, United States, 10Arkansas Children's Hospital, Little Rock, AR, United States, 11Texas Department of State Health Services, Austin, TX, United States, 12California Department of Public Health, Richmond, CA, United States, 13University of South Florida, Tampa, FL, United States


3:10 PM–3:20 PM
34
Prevalence of Select Brain and Eye Defects Potentially Related to Zika Virus in Pregnancy
Delaney AM1, Olson SE2, Roth NM1, Cragan J3, Godfred-Cato S3, Fornoff J4, Nestoridi E5, Forkner A6, Stolz A7, Cho SJ8, Knapp M9, Crawford K10, Breidenbach R11, Nance A12, Elmore AL13, Denson L14, Forestieri N15, Leedom V16, Tran T17, Romitti PA18, Valencia M19, Barton J20, St. John K21, Kimura J22, Orantes L23, Ellis EM24, Tong VT3, Gilboa SM3, Moore CA3, Honein MA3. 1Eagle Global Scientific, LLC, Atlanta, GA, United States, 2G2S Corporation, San Antonio, TX, United States, 3National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GA, United States, 4Illinois Department of Public Health, Springfield, IL, United States, 5Massachusetts Department of Public Health, Boston, MA, United States, 6Indiana State Health Department, Indianapolis, IN, United States, 7New York State Department of Health, Bureau of Environmental & Occupational Epidemiology, Albany, NY, United States, 8Minnesota Department of Health, St. Paul, MN, United States, 9New Jersey Department of Health, Trenton, NJ, United States, 10Virginia Department of Health, Richmond, VA, United States, 11Birth Defects Epidemiology and Surveillance Branch, TX Department of State Health Services, Austin, TX, United States, 12Utah Department of Health, Salt Lake City, UT, United States, 13Florida Department of Health, Tallahassee, FL, United States, 14Oklahoma State Department of Health, Oklahoma City, OK, United States, 15North Carolina Department of Health and Human Services, Raleigh, NC, United States, 16South Carolina Dept. of Health & Environmental Control, Columbia, SC, United States, 17Louisiana Department of Health, New Orleans, LA, United States, 18University of Iowa, Iowa, IA, United States, 19Puerto Rico Department of Health, San Juan, PR, United States, 20Georgia Department of Public Health, Atlanta, GA, United States, 21Rhode Island Department of Health, Providence, RI, United States, 22Hawaii Department of Health, Honolulu, HI, United States, 23Vermont Department of Health, Burlington, VT, United States, 24US Virgin Islands Department of Health, Christiansted, US Virgin Islands, United States


3:30 PM–4:30 PM
Closing Session: Awards Announcements and Annual Business Meeting




EDUCATION COURSES

Thursday, July 16, 2020
11:00 AM–12:30 PM
Education Course 1:
Embryology and Toxicity of the Developing Immune System (Separate Registration Required)

Organized by the Education Committee
Chairperson: Caren Villano, Bristol-Myers Squibb

Full Schedule


11:00 AM–11:05 AM
Course Overview
Education Committee, Chairperson, Caren Villano, Bristol-Myers Squibb


11:05 AM–11:20 AM
Immunotoxicology Overview
Jeanine L. Bussiere, Amgen, Inc.


11:20 AM–11:45 AM
Comparative Development of the Immune System
John Krayer, Janssen


11:45 AM–12:15 PM
Developmental Immunotoxicology
Jamie C. DeWitt, East Carolina University


12:15 AM–12:30 PM
Questions and Answers




Thursday, July 23, 2020
11:00 AM–2:30 PM
Education Course 2:
Juvenile Toxicology (Separate Registration Required)

Organized by the Education Committee
Chairperson: Caren Villano, Bristol-Myers Squibb

Full Schedule


11:00 AM–11:05 AM
Course Overview
Education Committee, Chairperson, Caren Villano, Bristol-Myers Squibb


11:05 AM–11:45 AM
Overview of Juvenile Toxicology
Jia Yao, US Food and Drug Administration


11:45 AM–12:25 PM
Approaches to Juvenile Animal Testing
Susan Bielmeier Laffan, GlaxoSmithKline


12:25 PM–12:40 PM
Questions and Answers


12:40 PM–12:55 PM
Break


12:55 PM–1:35 PM
Postnatal Organ System Development in Nonclinical Species
Wendy Halpern, Genentech


1:35 PM–2:15 PM
Clinical Relevance for Pediatric Populations
Susan McCune, US Food and Drug Administration


2:15 PM–2:30 PM
Questions and Answers



Thursday, July 30, 2020
11:00 AM–12:30 PM
Education Course 3:
Assessment of Ovarian Toxicity (Separate Registration Required)

Organized by the Education Committee
Chairperson: Caren Villano, Bristol-Myers Squibb

Full Schedule


11:00 AM–11:05 AM
Course Overview
Education Committee, Chairperson, Caren Villano, Bristol-Myers Squibb


11:05 AM–11:35 AM
Counting Ovarian Follicles with a Deep Learning Algorithm in Rats
Heike Antje Marxfeld, BASF


11:35 PM–12:05 PM
In Vitro Ovarian Models: The Use of Cutting-Edge Technologies to Develop an In Vitro High-Throughput Female Ovarian Toxicity Screening Platform
Shuo Xiao, University of South Carolina


12:05 PM–12:30 PM
Questions and Answers